000121138 001__ 121138
000121138 005__ 20240319081007.0
000121138 0247_ $$2doi$$a10.1523/JNEUROSCI.1885-21.2022
000121138 0248_ $$2sideral$$a131697
000121138 037__ $$aART-2022-131697
000121138 041__ $$aeng
000121138 100__ $$aBräcklein, Mario
000121138 245__ $$aReading and modulating Cortical ß rursts from motor unit spiking activity
000121138 260__ $$c2022
000121138 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121138 5203_ $$aβ Oscillations (13–30 Hz) are ubiquitous in the human motor nervous system. Yet, their origins and roles are unknown. Traditionally, β activity has been treated as a stationary signal. However, recent studies observed that cortical β occurs in “bursting events,” which are transmitted to muscles. This short-lived nature of β events makes it possible to study the main mechanism of β activity found in the muscles in relation to cortical β. Here, we assessed whether muscle β activity mainly results from cortical projections. We ran two experiments in healthy humans of both sexes (N = 15 and N = 13, respectively) to characterize β activity at the cortical and motor unit (MU) levels during isometric contractions of the tibialis anterior muscle. We found that β rhythms observed at the cortical and MU levels are indeed in bursts. These bursts appeared to be time-locked and had comparable average durations (40–80 ms) and rates (approximately three to four bursts per second). To further confirm that cortical and MU β have the same source, we used a novel operant conditioning framework to allow subjects to volitionally modulate MU β. We showed that volitional modulation of β activity at the MU level was possible with minimal subject learning and was paralleled by similar changes in cortical β activity. These results support the hypothesis that MU β mainly results from cortical projections. Moreover, they demonstrate the possibility to decode cortical β activity from MU recordings, with a potential translation to future neural interfaces that use peripheral information to identify and modulate activity in the central nervous system.
000121138 536__ $$9info:eu-repo/grantAgreement/EC/H2020/847648 /EU/Junior Leader la Caixa Postdoctoral Fellowship Programme: Shaping the new generation of leaders in research/JUNIOR LEADER$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 847648 -JUNIOR LEADER$$9info:eu-repo/grantAgreement/EC/H2020/899626/EU/NIMA: Non-invasive Interface for Movement Augmentation/NIMA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 899626-NIMA
000121138 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121138 590__ $$a5.3$$b2022
000121138 592__ $$a2.35$$b2022
000121138 591__ $$aNEUROSCIENCES$$b62 / 272 = 0.228$$c2022$$dQ1$$eT1
000121138 593__ $$aNeuroscience (miscellaneous)$$c2022$$dQ1
000121138 594__ $$a9.9$$b2022
000121138 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121138 700__ $$aBarsakcioglu, Deren Y.
000121138 700__ $$aDel Vecchio, Alessandro
000121138 700__ $$0(orcid)0000-0001-8439-151X$$aIbáñez, Jaime
000121138 700__ $$aFarina, Dario
000121138 773__ $$g42, 17 (2022), 3611-3621$$pJ. neurosci.$$tJOURNAL OF NEUROSCIENCE$$x0270-6474
000121138 8564_ $$s2964694$$uhttps://zaguan.unizar.es/record/121138/files/texto_completo.pdf$$yVersión publicada
000121138 8564_ $$s3115388$$uhttps://zaguan.unizar.es/record/121138/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121138 909CO $$ooai:zaguan.unizar.es:121138$$particulos$$pdriver
000121138 951__ $$a2024-03-18-14:47:10
000121138 980__ $$aARTICLE