121138 20240319081007.0 doi 10.1523/JNEUROSCI.1885-21.2022 sideral 131697 ART-2022-131697 eng Bräcklein, Mario Reading and modulating Cortical ß rursts from motor unit spiking activity 2022 Access copy available to the general public Unrestricted β Oscillations (13–30 Hz) are ubiquitous in the human motor nervous system. Yet, their origins and roles are unknown. Traditionally, β activity has been treated as a stationary signal. However, recent studies observed that cortical β occurs in “bursting events,” which are transmitted to muscles. This short-lived nature of β events makes it possible to study the main mechanism of β activity found in the muscles in relation to cortical β. Here, we assessed whether muscle β activity mainly results from cortical projections. We ran two experiments in healthy humans of both sexes (N = 15 and N = 13, respectively) to characterize β activity at the cortical and motor unit (MU) levels during isometric contractions of the tibialis anterior muscle. We found that β rhythms observed at the cortical and MU levels are indeed in bursts. These bursts appeared to be time-locked and had comparable average durations (40–80 ms) and rates (approximately three to four bursts per second). To further confirm that cortical and MU β have the same source, we used a novel operant conditioning framework to allow subjects to volitionally modulate MU β. We showed that volitional modulation of β activity at the MU level was possible with minimal subject learning and was paralleled by similar changes in cortical β activity. These results support the hypothesis that MU β mainly results from cortical projections. Moreover, they demonstrate the possibility to decode cortical β activity from MU recordings, with a potential translation to future neural interfaces that use peripheral information to identify and modulate activity in the central nervous system. info:eu-repo/grantAgreement/EC/H2020/847648 /EU/Junior Leader la Caixa Postdoctoral Fellowship Programme: Shaping the new generation of leaders in research/JUNIOR LEADER This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 847648 -JUNIOR LEADER info:eu-repo/grantAgreement/EC/H2020/899626/EU/NIMA: Non-invasive Interface for Movement Augmentation/NIMA This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 899626-NIMA info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.3 2022 NEUROSCIENCES 62 / 272 = 0.228 2022 Q1 T1 2.35 2022 Neuroscience (miscellaneous) 2022 Q1 9.9 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Barsakcioglu, Deren Y. Del Vecchio, Alessandro Ibáñez, Jaime (orcid)0000-0001-8439-151X Farina, Dario 42, 17 (2022), 3611-3621 J. neurosci. JOURNAL OF NEUROSCIENCE 0270-6474 2964694 http://zaguan.unizar.es/record/121138/files/texto_completo.pdf Versión publicada 3115388 http://zaguan.unizar.es/record/121138/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121138 articulos driver 2024-03-18-14:47:10 ARTICLE