000121173 001__ 121173
000121173 005__ 20240319081015.0
000121173 0247_ $$2doi$$a10.3390/jcm11154518
000121173 0248_ $$2sideral$$a131825
000121173 037__ $$aART-2022-131825
000121173 041__ $$aeng
000121173 100__ $$aChaparro, María
000121173 245__ $$aUsing Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn’s Disease Patients on Ustekinumab
000121173 260__ $$c2022
000121173 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121173 5203_ $$aUstekinumab has shown efficacy in Crohn’s Disease (CD) patients. To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of CD and generate hypotheses for future trials. The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning. Patients’ data from SUSTAIN, a retrospective multicenter single-arm cohort study, were used. Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented. Clinical remission was defined as the Harvey Bradshaw Index ≤ 4 and was tracked longitudinally. Drug durability was defined as the time until a patient discontinued treatment. A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered. Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model. Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission.
000121173 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121173 590__ $$a3.9$$b2022
000121173 592__ $$a0.935$$b2022
000121173 591__ $$aMEDICINE, GENERAL & INTERNAL$$b58 / 169 = 0.343$$c2022$$dQ2$$eT2
000121173 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000121173 594__ $$a5.4$$b2022
000121173 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121173 700__ $$aBaston-Rey, Iria
000121173 700__ $$aFernández Salgado, Estela
000121173 700__ $$aGonzález García, Javier
000121173 700__ $$aRamos, Laura
000121173 700__ $$aDiz-Lois Palomares, María Teresa
000121173 700__ $$aArgüelles-Arias, Federico
000121173 700__ $$aIglesias Flores, Eva
000121173 700__ $$aCabello, Mercedes
000121173 700__ $$aRubio Iturria, Saioa
000121173 700__ $$aNúñez Ortiz, Andrea
000121173 700__ $$aCharro, Mara
000121173 700__ $$aGinard, Daniel
000121173 700__ $$aDueñas Sadornil, Carmen
000121173 700__ $$aMerino Ochoa, Olga
000121173 700__ $$aBusquets, David
000121173 700__ $$aIyo, Eduardo
000121173 700__ $$aGutiérrez Casbas, Ana
000121173 700__ $$aRamírez de la Piscina, Patricia
000121173 700__ $$aBoscá-Watts, Marta Maia
000121173 700__ $$aArroyo, Maite
000121173 700__ $$aGarcía, María José
000121173 700__ $$aHinojosa, Esther
000121173 700__ $$aGordillo, Jordi
000121173 700__ $$aMartínez Montiel, Pilar
000121173 700__ $$aVelayos Jiménez, Benito
000121173 700__ $$aQuílez Ivorra, Cristina
000121173 700__ $$aVázquez Morón, Juan María
000121173 700__ $$aHuguet, José María
000121173 700__ $$aGonzález-Lama, Yago
000121173 700__ $$aMuñagorri Santos, Ana Isabel
000121173 700__ $$aAmo, Víctor Manuel
000121173 700__ $$aMartín Arranz, María Dolores
000121173 700__ $$aBermejo, Fernando
000121173 700__ $$aMartínez Cadilla, Jesús
000121173 700__ $$aRubín de Célix, Cristina
000121173 700__ $$aFradejas Salazar, Paola
000121173 700__ $$aLópez San Román, Antonio
000121173 700__ $$aJiménez, Nuria
000121173 700__ $$0(orcid)0000-0003-3970-5457$$aGarcía-López, Santiago$$uUniversidad de Zaragoza
000121173 700__ $$aFiguerola, Anna
000121173 700__ $$aJiménez, Itxaso
000121173 700__ $$aMartínez Cerezo, Francisco José
000121173 700__ $$aTaxonera, Carlos
000121173 700__ $$aVarela, Pilar
000121173 700__ $$ade Francisco, Ruth
000121173 700__ $$aMonfort, David
000121173 700__ $$aMolina Arriero, Gema
000121173 700__ $$aHernández-Camba, Alejandro
000121173 700__ $$aGarcía Alonso, Francisco Javier
000121173 700__ $$aVan Domselaar, Manuel
000121173 700__ $$aPajares-Villarroya, Ramón
000121173 700__ $$aNúñez, Alejandro
000121173 700__ $$aRodríguez Moranta, Francisco
000121173 700__ $$aMarín-Jiménez, Ignacio
000121173 700__ $$aRobles Alonso, Virginia
000121173 700__ $$aMartín Rodríguez, María del Mar
000121173 700__ $$aCamo-Monterde, Patricia
000121173 700__ $$aGarcía Tercero, Iván
000121173 700__ $$aNavarro-Llavat, Mercedes
000121173 700__ $$aGarcía, Lara Arias
000121173 700__ $$aHervías Cruz, Daniel
000121173 700__ $$aKloss, Sebastian
000121173 700__ $$aPassey, Alun
000121173 700__ $$aNovella, Cynthia
000121173 700__ $$aVispo, Eugenia
000121173 700__ $$aBarreiro-de Acosta, Manuel
000121173 700__ $$aGisbert, Javier P.
000121173 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000121173 773__ $$g11, 15 (2022), 4518 [17 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000121173 8564_ $$s1542141$$uhttps://zaguan.unizar.es/record/121173/files/texto_completo.pdf$$yVersión publicada
000121173 8564_ $$s3347867$$uhttps://zaguan.unizar.es/record/121173/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121173 909CO $$ooai:zaguan.unizar.es:121173$$particulos$$pdriver
000121173 951__ $$a2024-03-18-15:34:49
000121173 980__ $$aARTICLE