000121174 001__ 121174
000121174 005__ 20240319081015.0
000121174 0247_ $$2doi$$a10.3390/jcm11133915
000121174 0248_ $$2sideral$$a131826
000121174 037__ $$aART-2022-131826
000121174 041__ $$aeng
000121174 100__ $$aRiestra, Sabino
000121174 245__ $$aPerformance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU
000121174 260__ $$c2022
000121174 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121174 5203_ $$a(1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-ץ-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18–20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50–0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66–0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20–22%] vs. 14% [95% CI 13–16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM.
000121174 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121174 590__ $$a3.9$$b2022
000121174 592__ $$a0.935$$b2022
000121174 591__ $$aMEDICINE, GENERAL & INTERNAL$$b58 / 169 = 0.343$$c2022$$dQ2$$eT2
000121174 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000121174 594__ $$a5.4$$b2022
000121174 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121174 700__ $$aTaxonera, Carlos
000121174 700__ $$aZabana, Yamile
000121174 700__ $$aCarpio, Daniel
000121174 700__ $$aChaparro, María
000121174 700__ $$aBarrio, Jesús
000121174 700__ $$aRivero, Montserrat
000121174 700__ $$aLópez-Sanroman, Antonio
000121174 700__ $$aEsteve, María
000121174 700__ $$ade Francisco, Ruth
000121174 700__ $$aBastida, Guillermo
000121174 700__ $$0(orcid)0000-0003-3970-5457$$aGarcía-López, Santiago$$uUniversidad de Zaragoza
000121174 700__ $$aMañosa, Miriam
000121174 700__ $$aMartin-Arranz, María Dolores
000121174 700__ $$aPérez-Calle, José Lázaro
000121174 700__ $$aGuardiola, Jordi
000121174 700__ $$aMuñoz, Fernando
000121174 700__ $$aArranz, Laura
000121174 700__ $$aCabriada, José Luis
000121174 700__ $$aGarcía-Sepulcre, Mariana Fe
000121174 700__ $$aNavarro, Mercè
000121174 700__ $$aMontoro-Huguet, Miguel Ángel
000121174 700__ $$aRicart, Elena
000121174 700__ $$aBermejo, Fernando
000121174 700__ $$aCalvet, Xavier
000121174 700__ $$aPiqueras, Marta
000121174 700__ $$aGarcia-Planella, Esther
000121174 700__ $$aMárquez, Lucía
000121174 700__ $$aMínguez, Miguel
000121174 700__ $$aVan Domselar, Manuel
000121174 700__ $$aBujanda, Luis
000121174 700__ $$aAldeguer, Xavier
000121174 700__ $$aSicilia, Beatriz
000121174 700__ $$aIglesias, Eva
000121174 700__ $$aAlcaín, Guillermo
000121174 700__ $$aPérez-Martínez, Isabel
000121174 700__ $$aRolle, Valeria
000121174 700__ $$aCastaño-García, Andrés
000121174 700__ $$aP. Gisbert, Javier
000121174 700__ $$aDomènech, Eugeni
000121174 700__ $$a
000121174 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000121174 773__ $$g11, 13 (2022), 3915 [12 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000121174 8564_ $$s458273$$uhttps://zaguan.unizar.es/record/121174/files/texto_completo.pdf$$yVersión publicada
000121174 8564_ $$s3111471$$uhttps://zaguan.unizar.es/record/121174/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121174 909CO $$ooai:zaguan.unizar.es:121174$$particulos$$pdriver
000121174 951__ $$a2024-03-18-15:34:55
000121174 980__ $$aARTICLE