Nationwide COVID-19-EII Study: Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry

Zabana, Yamile ; Marín-Jiménez, Ignacio ; Rodríguez-Lago, Iago ; Vera, Isabel ; Martín-Arranz, María Dolores ; Guerra, Iván ; Gisbert, Javier P. ; Mesonero, Francisco ; Benítez, Olga ; Taxonera, Carlos ; Ponferrada-Díaz, Ángel ; Piqueras, Marta ; Lucendo, Alfredo J. ; Caballol, Berta ; Mañosa, Míriam ; Martínez-Montiel, Pilar ; Bosca-Watts, Maia ; Gordillo, Jordi ; Bujanda, Luis ; Manceñido, Noemí ; Martínez-Pérez, Teresa ; López, Alicia ; Rodríguez-Gutiérrez, Cristina ; García-López, Santiago (Universidad de Zaragoza) ; Vega, Pablo ; Rivero, Montserrat ; Melcarne, Luigi ; Calvo, Maria ; Iborra, Marisa ; Barreiro de-Acosta, Manuel ; Sicilia, Beatriz ; Barrio, Jesús ; Pérez, José Lázaro ; Busquets, David ; Pérez-Martínez, Isabel ; Navarro-Llavat, Mercè ; Hernández, Vicent ; Argüelles-Arias, Federico ; Ramírez Esteso, Fernando ; Meijide, Susana ; Ramos, Laura ; Gomollón, Fernando ; Muñoz, Fernando ; Suris, Gerard ; de Zarate, Jone Ortiz ; Huguet, José María ; Llaó, Jordina ; García-Sepulcre, Mariana Fe ; Sierra, Mónica ; Durà, Miguel ; Estrecha, Sandra ; Fuentes Coronel, Ana ; Hinojosa, Esther ; Olivan, Lorenzo ; Iglesias, Eva ; Gutiérrez, Ana ; Varela, Pilar ; Rull, Núria ; Gilabert, Pau ; Hernández-Camba, Alejandro ; Brotons, Alicia ; Ginard, Daniel ; Sesé, Eva ; Carpio, Daniel ; Aceituno, Montserrat ; Cabriada, José Luis ; González-Lama, Yago ; Jiménez, Laura ; Chaparro, María ; López-San Román, Antonio ; Alba, Cristina ; Plaza-Santos, Rocío ; Mena, Raquel ; Tamarit-Sebastián, Sonsoles ; Ricart, Elena ; Calafat, Margalida ; Olivares, Sonsoles ; Navarro, Pablo ; Bertoletti, Federico ; Alonso-Galán, Horacio ; Pajares, Ramón ; Olcina, Pablo ; Manzano, Pamela ; Domènech, Eugeni ; Esteve, Maria ;

Resumen: We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA registry (53,682 from 73 centres) between March–July 2020 followed-up for 12 months. Results were compared with data of the general population (National Centre of Epidemiology and Catalonia). A total of 482 patients with COVID-19 were identified. Twenty-eight percent were infected in the work environment, and 48% were infected by intrafamilial transmission, despite having good adherence to lockdown. Thirty-five percent required hospitalization, 7.9% had severe COVID-19 and 3.7% died. Similar data were reported in the general population (hospitalisation 19.5%, ICU 2.1% and mortality 4.6%). Factors related to death and severe COVID-19 were being aged ≥ 60 years (OR 7.1, 95% CI: 1.8–27 and 4.5, 95% CI: 1.3–15.9), while having ≥2 comorbidities increased mortality (OR 3.9, 95% CI: 1.3–11.6). None of the drugs for IBD were related to severe COVID-19. Immunosuppression was definitively stopped in 1% of patients at 12 months. The prognosis of COVID-19 in IBD, even in immunosuppressed patients, is similar to that in the general population. Thus, there is no need for more strict protection measures in IBD.

Idioma: Inglés

DOI: 10.3390/jcm11020421

Año: 2022

Publicado en: Journal of Clinical Medicine 11, 2 (2022), 421 [20 pp.]
ISSN: 2077-0383

Factor impacto JCR: 3.9 (2022)

Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 58 / 169 = 0.343 (2022) - Q2 - T2

Factor impacto CITESCORE: 5.4 - Medicine (Q2)

Factor impacto SCIMAGO: 0.935 - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/COV20-00227

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)