000121224 001__ 121224 000121224 005__ 20240705134139.0 000121224 0247_ $$2doi$$a10.1111/ejh.13900 000121224 0248_ $$2sideral$$a131641 000121224 037__ $$aART-2023-131641 000121224 041__ $$aeng 000121224 100__ $$aCruz-Montecinos, C. 000121224 245__ $$aEffectiveness of progressive moderate-vigorous intensity elastic resistance training on quality of life and perceived functional abilities in people with hemophilia: Secondary analysis of a randomized controlled trial 000121224 260__ $$c2023 000121224 5060_ $$aAccess copy available to the general public$$fUnrestricted 000121224 5203_ $$aIntroduction and Aim: Strength exercise training is advised for people with hemophilia (PWH); however, few studies have been published and have methodological limitations. The purpose of this study was to evaluate the effectiveness of progressive elastic resistance training on quality of life and perceived functional abilities in PWH. Methods: Participants were randomly allocated to the intervention (n = 10) or control (n = 10) group. The intervention group performed progressive moderate-vigorous elastic resistance training (2 days/week, a total of 8 weeks), focusing on the muscles of the knee, elbow, and ankle joints. The control group continued its usual daily activities for 8 weeks. Quality of life (A36 Hemofilia-QoL®) and perceived functional abilities (Haemophilia Activities List) were assessed at baseline and an 8-week follow-up. Results: The intervention group improved the quality-of-life dimension of joint damage perception in comparison to the control group (p = .015, large effect size). Regarding perceived functional abilities, the intervention group improved lying, sitting, kneeling, and standing (p = .006, small effect size), and complex lower extremities activities (i.e., walking short and long-distance, and up-down stairs) (p = .006, small effect size) compared to the control group. No other significant differences were observed. Conclusions: Eight weeks of progressive moderate-vigorous elastic resistance training in PWH improve the quality-of-life dimension of joint damage perception and perceived functional abilities (lying/sitting/kneeling/standing, and complex lower extremities activities). Our results suggest a limited effect of the program on the other items of quality of life measured by the questionnaire as emotional functioning, mental health, and social relationships. Importantly, no serious adverse effects occurred. 000121224 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000121224 592__ $$a0.944$$b2023 000121224 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1 000121224 593__ $$aHematology$$c2023$$dQ2 000121224 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000121224 700__ $$aPérez-Alenda, S. 000121224 700__ $$aCasaña, J. 000121224 700__ $$aCarrasco, J. J. 000121224 700__ $$aAndersen, L. L. 000121224 700__ $$0(orcid)0000-0002-7865-3429$$aLópez Bueno, R. 000121224 700__ $$aNuñez-Cortés, R. 000121224 700__ $$aBonanad, S. 000121224 700__ $$aQuerol, F. 000121224 700__ $$aCalatayud, J. 000121224 773__ $$g110, 3 (2023), 253-261$$pEur. j. haematol.$$tEUROPEAN JOURNAL OF HAEMATOLOGY$$x0902-4441 000121224 8564_ $$s907722$$uhttps://zaguan.unizar.es/record/121224/files/texto_completo.pdf$$yVersión publicada 000121224 8564_ $$s1961682$$uhttps://zaguan.unizar.es/record/121224/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000121224 909CO $$ooai:zaguan.unizar.es:121224$$particulos$$pdriver 000121224 951__ $$a2024-07-05-12:46:22 000121224 980__ $$aARTICLE