121314 20240319081006.0 doi 10.3390/nu14030405 sideral 131895 ART-2022-131895 eng Valls, Rosa M. Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study 2022 Access copy available to the general public Unrestricted The consumption of aged black garlic (ABG) has been related to improvements in several cardiovascular disease (CVD) risk factors. However, the extent of the beneficial effects depends on the garlic aging process and the amount and type of chemical compounds accumulated. The main objective of this study was to assess the effect of daily intake of a well-characterized ABG extract with a standardized S-allyl-L-cysteine (SAC) yield in combination with dietary recommendations regarding CVD risk factors in individuals with moderate hypercholesterolemia. Sixty-seven hypercholesterolemic individuals with low-density lipoprotein cholesterol levels ≥115 mg/dL were randomized in a crossover, double-blind, sustained, and controlled intervention study. The participants consumed 250 mg (1.25 mg SAC)/tablet/day ABG or a placebo for 6 weeks, with 3 weeks of washout. Blood and pulse pressure and other CVD risk biomarkers were determined at the beginning and end of each intervention. At 6 weeks, ABG extract reduced diastolic blood pressure (DBP) (mean (95% CI) −5.85 (−10.5; −1.3) mm Hg) compared to the placebo, particularly in men with a DBP > 75 mm Hg. The consumption of an improved ABG extract with 1.25 mg of SAC decreased DBP, particularly in men with moderate hypercholesterolemia. The potential beneficial effects of ABG may contribute to obtaining an optimal DBP. info:eu-repo/grantAgreement/ES/MICINN/CDTI-20180389 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.9 2022 NUTRITION & DIETETICS 17 / 87 = 0.195 2022 Q1 T1 1.291 2022 Nutrition and Dietetics 2022 Q1 Food Science 2022 Q1 9.0 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Companys, Judit Calderón-Pérez, Lorena Salamanca, Patricia Pla-Pagà, Laura Sandoval-Ramírez, Berner Andrée Bueno, Antonio Universidad de Zaragoza (orcid)0000-0003-0274-8306 Puzo, Jose Universidad de Zaragoza (orcid)0000-0002-1309-4363 Crescenti, Anna Bas, Josep M. del Caimari, Antoni Salamanca, Aurora Espinel, Alberto E. Pedret, Anna Arola, Lluís Solà, Rosa 1013 830 Universidad de Zaragoza Dpto. Cirugía Área Traumatología y Ortopedia 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 14, 3 (2022), 405 [18 pp.] Nutrients Nutrients 2072-6643 678775 http://zaguan.unizar.es/record/121314/files/texto_completo.pdf Versión publicada 2788813 http://zaguan.unizar.es/record/121314/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121314 articulos driver 2024-03-18-14:42:02 ARTICLE