000121330 001__ 121330
000121330 005__ 20230519145624.0
000121330 0247_ $$2doi$$a10.3390/polym13193399
000121330 0248_ $$2sideral$$a131314
000121330 037__ $$aART-2021-131314
000121330 041__ $$aeng
000121330 100__ $$aRen, Jiongyu
000121330 245__ $$aPoly-e-Caprolactone/Fibrin-Alginate scaffold: a new Pro-Angiogenic composite biomaterial for the treatment of bone defects
000121330 260__ $$c2021
000121330 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121330 5203_ $$aWe hypothesized that a composite of 3D porous melt-electrowritten poly-ɛ-caprolactone (PCL) coated throughout with a porous and slowly biodegradable fibrin/alginate (FA) matrix would accelerate bone repair due to its angiogenic potential. Scanning electron microscopy showed that the open pore structure of the FA matrix was maintained in the PCL/FA composites. Fourier transform infrared spectroscopy and differential scanning calorimetry showed complete coverage of the PCL fibres by FA, and the PCL/FA crystallinity was decreased compared with PCL. In vitro cell work with osteoprogenitor cells showed that they preferentially bound to the FA component and proliferated on all scaffolds over 28 days. A chorioallantoic membrane assay showed more blood vessel infiltration into FA and PCL/FA compared with PCL, and a significantly higher number of bifurcation points for PCL/FA compared with both FA and PCL. Implantation into a rat cranial defect model followed by microcomputed tomography, histology, and immunohistochemistry after 4- and 12-weeks post operation showed fast early bone formation at week 4, with significantly higher bone formation for FA and PCL/FA compared with PCL. However, this phenomenon was not extrapolated to week 12. Therefore, for long-term bone regeneration, tuning of FA degradation to ensure syncing with new bone formation is likely necessary.
000121330 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121330 590__ $$a4.967$$b2021
000121330 591__ $$aPOLYMER SCIENCE$$b16 / 90 = 0.178$$c2021$$dQ1$$eT1
000121330 592__ $$a0.726$$b2021
000121330 593__ $$aPolymers and Plastics$$c2021$$dQ1
000121330 593__ $$aChemistry (miscellaneous)$$c2021$$dQ1
000121330 594__ $$a5.7$$b2021
000121330 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121330 700__ $$aKohli, Nupur
000121330 700__ $$aSharma, Vaibhav
000121330 700__ $$aShakouri, Taleen
000121330 700__ $$aKeskin-Erdogan, Zalike
000121330 700__ $$aSaifzadeh, Siamak
000121330 700__ $$aBrierly, Gary I.
000121330 700__ $$aKnowles, Jonathan C.
000121330 700__ $$aWoodruff, Maria A.
000121330 700__ $$0(orcid)0000-0001-7062-9099$$aGarcía-Gareta, Elena
000121330 773__ $$g13, 19 (2021), 3399 [22 pp.]$$pPolymers (Basel)$$tPolymers$$x2073-4360
000121330 8564_ $$s11551393$$uhttps://zaguan.unizar.es/record/121330/files/texto_completo.pdf$$yVersión publicada
000121330 8564_ $$s2808675$$uhttps://zaguan.unizar.es/record/121330/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121330 909CO $$ooai:zaguan.unizar.es:121330$$particulos$$pdriver
000121330 951__ $$a2023-05-18-16:18:16
000121330 980__ $$aARTICLE