121352 20230914083533.0 doi 10.22489/CinC.2020.233 sideral 131527 ART-2020-131527 eng Kontaxis, Spyridon Universidad de Zaragoza (orcid)0000-0002-1297-0691 Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices 2020 Access copy available to the general public Unrestricted In this study, differences in autonomic reactivity to mental stress between Major Depressive Disorder (MDD) patients and healthy control (HC) subjects are assessed by nonlinear cardiorespiratory coupling indices derived from the Real Wavelet Biphase. The degree and strength of Quadratic Phase Coupling (QPC) between interacting oscillations of Heart Rate Variability (HRV) and respiration are quantified before, during and after the execution of acognitive task. Results show that the QPC strength and QPC degree between the respiration and the respiratory sinus arrhythmia component of HRV were lower in HC compared to MDD during stress, suggesting that the parasympathetic branch was less inhibited in MDD patients. During recovery, only in HC group, this degree of QPC increased, while the respiratory rate was reduced, compared to the basal stage. The degree of QPC between the respiration and components of HRV in the low frequency band ([0.04, 0.15] Hz) increased in HC during stress, compared to the basal stage, while remained unchanged in MDD patients. These results imply that depression is associated with blunted autonomic reactivity to mental stress info:eu-repo/grantAgreement/ES/AEI-FEDER/RTI2018-097723-B-I00 info:eu-repo/grantAgreement/ES/DGA-FSE/LMP44-18 info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 0.257 2020 Computer Science (miscellaneous) 2020 Cardiology and Cardiovascular Medicine 2020 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Laguna, Pablo Universidad de Zaragoza (orcid)0000-0003-3434-9254 García Pages, Esther Posadas-de Miguel, Mar Siddi, Sara Luisa Bernal, Maria Universidad de Zaragoza (orcid)0000-0002-8222-1418 Maria Haro, Josep Aguiló, Jordi de la Camara, Concepción Universidad de Zaragoza (orcid)0000-0003-2284-7862 Bailón, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Gil, Eduardo Universidad de Zaragoza (orcid)0000-0001-7285-0715 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 47 (2020), [4 pp.] Comput. cardiol. Computing in Cardiology 2325-8861 136891 http://zaguan.unizar.es/record/121352/files/texto_completo.pdf Versión publicada 2742224 http://zaguan.unizar.es/record/121352/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121352 articulos driver 2023-09-13-13:16:04 ARTICLE