000121360 001__ 121360
000121360 005__ 20240319081013.0
000121360 0247_ $$2doi$$a10.1016/J.CEJ.2021.134466
000121360 0248_ $$2sideral$$a129130
000121360 037__ $$aART-2022-129130
000121360 041__ $$aeng
000121360 100__ $$aZhong, Baihua
000121360 245__ $$aGraphene-encapsulated magnetic nanoparticles for safe and steady delivery of ferulic acid in diabetic mice
000121360 260__ $$c2022
000121360 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121360 5203_ $$aIron nanoparticles encapsulated within graphene shells (Fe@C) were examined for cellular internalization, subcellular behavior, biocompatibility, and influence on cell viability and proliferation. Studies on human lung (adenocarcinoma human alveolar basal epithelial) and skin (epidermoid carcinoma) cells indicate Fe@C is less toxic and more biocompatible than the magnetite nanoparticles coated by an amorphous carbon (Fe3O4@C). Fe3O4@C exhibited more signs of degradation than Fe@C when exposed to murine macrophages (mouse monocyte-macrophages J774). Unlike Fe3O4@C, Fe@C has a high drug loading capacity (0.18 g/g) for ferulic acid, an active pharmaceutical ingredient found in the traditional Chinese herb Angelica sinensis and releases the drug at a constant dosing rate of 8.75 mg/g/day over 30 days. Ferulic acid released by Fe@C injected subcutaneously in diabetic BALB/c mice is effective in lowering the blood glucose level.
000121360 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E28-20R$$9info:eu-repo/grantAgreement/ES/MICINN/DTS2019-00033$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-106947RB-C21$$9info:eu-repo/grantAgreement/ES/MINECO/PI16-00496$$9info:eu-repo/grantAgreement/ES/MINECO/PI19-00349
000121360 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000121360 590__ $$a15.1$$b2022
000121360 592__ $$a2.803$$b2022
000121360 591__ $$aENGINEERING, ENVIRONMENTAL$$b3 / 55 = 0.055$$c2022$$dQ1$$eT1
000121360 591__ $$aENGINEERING, CHEMICAL$$b5 / 141 = 0.035$$c2022$$dQ1$$eT1
000121360 593__ $$aChemical Engineering (miscellaneous)$$c2022$$dQ1
000121360 593__ $$aIndustrial and Manufacturing Engineering$$c2022$$dQ1
000121360 593__ $$aEnvironmental Chemistry$$c2022$$dQ1
000121360 593__ $$aChemistry (miscellaneous)$$c2022$$dQ1
000121360 594__ $$a21.5$$b2022
000121360 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000121360 700__ $$aMateu-Roldán, Adán
000121360 700__ $$aFanarraga, Mónica L.
000121360 700__ $$aHan, Wei
000121360 700__ $$aMuñoz-Guerra, Débora
000121360 700__ $$aGonzález, Jesús
000121360 700__ $$aTao Weng, Lu
000121360 700__ $$0(orcid)0000-0003-0681-8260$$aIbarra, M. Ricardo$$uUniversidad de Zaragoza
000121360 700__ $$0(orcid)0000-0003-0602-492X$$aMarquina, Clara
000121360 700__ $$aLun Yeung, King
000121360 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000121360 773__ $$g435, Part. 1 (2022), 134466$$pChem. eng. j.$$tChemical Engineering Journal$$x1385-8947
000121360 8564_ $$s3262591$$uhttps://zaguan.unizar.es/record/121360/files/texto_completo.pdf$$yPostprint
000121360 8564_ $$s1342558$$uhttps://zaguan.unizar.es/record/121360/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000121360 909CO $$ooai:zaguan.unizar.es:121360$$particulos$$pdriver
000121360 951__ $$a2024-03-18-15:23:26
000121360 980__ $$aARTICLE