121360 20240319081013.0 doi 10.1016/J.CEJ.2021.134466 sideral 129130 ART-2022-129130 eng Zhong, Baihua Graphene-encapsulated magnetic nanoparticles for safe and steady delivery of ferulic acid in diabetic mice 2022 Access copy available to the general public Unrestricted Iron nanoparticles encapsulated within graphene shells (Fe@C) were examined for cellular internalization, subcellular behavior, biocompatibility, and influence on cell viability and proliferation. Studies on human lung (adenocarcinoma human alveolar basal epithelial) and skin (epidermoid carcinoma) cells indicate Fe@C is less toxic and more biocompatible than the magnetite nanoparticles coated by an amorphous carbon (Fe3O4@C). Fe3O4@C exhibited more signs of degradation than Fe@C when exposed to murine macrophages (mouse monocyte-macrophages J774). Unlike Fe3O4@C, Fe@C has a high drug loading capacity (0.18 g/g) for ferulic acid, an active pharmaceutical ingredient found in the traditional Chinese herb Angelica sinensis and releases the drug at a constant dosing rate of 8.75 mg/g/day over 30 days. Ferulic acid released by Fe@C injected subcutaneously in diabetic BALB/c mice is effective in lowering the blood glucose level. info:eu-repo/grantAgreement/ES/DGA/E28-20R info:eu-repo/grantAgreement/ES/MICINN/DTS2019-00033 info:eu-repo/grantAgreement/ES/MICINN/PID2019-106947RB-C21 info:eu-repo/grantAgreement/ES/MINECO/PI16-00496 info:eu-repo/grantAgreement/ES/MINECO/PI19-00349 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 15.1 2022 ENGINEERING, ENVIRONMENTAL 3 / 55 = 0.055 2022 Q1 T1 ENGINEERING, CHEMICAL 5 / 141 = 0.035 2022 Q1 T1 2.803 2022 Chemical Engineering (miscellaneous) 2022 Q1 Industrial and Manufacturing Engineering 2022 Q1 Environmental Chemistry 2022 Q1 Chemistry (miscellaneous) 2022 Q1 21.5 2022 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Mateu-Roldán, Adán Fanarraga, Mónica L. Han, Wei Muñoz-Guerra, Débora González, Jesús Tao Weng, Lu Ibarra, M. Ricardo Universidad de Zaragoza (orcid)0000-0003-0681-8260 Marquina, Clara (orcid)0000-0003-0602-492X Lun Yeung, King 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 435, Part. 1 (2022), 134466 Chem. eng. j. Chemical Engineering Journal 1385-8947 3262591 http://zaguan.unizar.es/record/121360/files/texto_completo.pdf Postprint 1342558 http://zaguan.unizar.es/record/121360/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:121360 articulos driver 2024-03-18-15:23:26 ARTICLE