121380 20241125101127.0 doi 10.3390/ijms24010471 sideral 131894 ART-2023-131894 eng Ruiz Pesini, Eduardo Universidad de Zaragoza (orcid)0000-0002-0269-7337 Mitochondrial genetic background may impact statins side effects and atherosclerosis development in familial hypercholesterolemia 2023 Access copy available to the general public Unrestricted Heredity of familial hypercholesterolemia (FH) can present as a dominant monogenic disorder of polygenic origin or with no known genetic cause. In addition, the variability of the symptoms among individuals or within the same families evidence the potential contribution of additional factors than monogenic mutations that could modulate the development and severity of the disease. In addition, statins, the lipid-lowering drugs which constitute the first-line therapy for the disease, cause associated muscular symptoms in a certain number of individuals. Here, we analyze the evidence of the mitochondrial genetic variation with a special emphasis on the role of CoQ10 to explain this variability found in both disease symptoms and statins side effects. We propose to use mtDNA variants and copy numbers as markers for the cardiovascular disease development of FH patients and to predict potential statin secondary effects and explore new mechanisms to identify new markers of disease or implement personalized medicine strategies for FH therapy. info:eu-repo/grantAgreement/ES/DGA/B33-20R info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA/LMP22_21 info:eu-repo/grantAgreement/EUR/ERDF-ESF/Investing in your future info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-00229 info:eu-repo/grantAgreement/ES/MICINN/PID2020-116970GA-I00 info:eu-repo/grantAgreement/ES/MICINN/RYC2020-029544-I info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.9 2023 BIOCHEMISTRY & MOLECULAR BIOLOGY 66 / 313 = 0.211 2023 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 68 / 231 = 0.294 2023 Q2 T1 1.179 2023 Medicine (miscellaneous) 2023 Q1 Physical and Theoretical Chemistry 2023 Q1 Computer Science Applications 2023 Q1 Inorganic Chemistry 2023 Q1 Spectroscopy 2023 Q1 Organic Chemistry 2023 Q1 Molecular Biology 2023 Q2 Catalysis 2023 Q2 8.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bayona Bafaluy, María Pilar Universidad de Zaragoza (orcid)0000-0002-8585-6371 Sanclemente, Teresa Universidad de Zaragoza (orcid)0000-0002-5407-3876 Puzo, José Universidad de Zaragoza (orcid)0000-0002-1309-4363 Montoya, Julio Universidad de Zaragoza (orcid)0000-0003-1770-6299 Pacheu Grau, David Universidad de Zaragoza (orcid)0000-0003-2645-3983 2008 640 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Nutrición Bromatología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 24, 1 (2023), 471 [10 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 293158 http://zaguan.unizar.es/record/121380/files/texto_completo.pdf Versión publicada 2781530 http://zaguan.unizar.es/record/121380/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121380 articulos driver 2024-11-22-11:57:52 ARTICLE