000121450 001__ 121450
000121450 005__ 20230126110117.0
000121450 0247_ $$2doi$$a10.26754/jji-i3a.201711983
000121450 0248_ $$2sideral$$a131938
000121450 037__ $$aART-2019-131938
000121450 041__ $$aeng
000121450 100__ $$aGonzález Lana, Sandra
000121450 245__ $$aNew Structured Materials in the Study of the Mechanobiological Processes Related to the Heart Failure
000121450 260__ $$c2019
000121450 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121450 5203_ $$aCardiovascular diseases are the number one of death globally. According to the World Health organization 17.7 million people died from cardiovascular diseases in 2015, representing 31% of all global deaths. In these diseases the cardiac homeostasis is disrupted by a non-appropriate myocardium remodelling. The cardiac extracellular matrix (ECM) provides not only the biochemical environment but also a natural scaffold surrounding and connecting cardiac cells and distributing mechanical forces throughout the organ. Thus, the properties of the ECM are essential for the maintenance of the functional myocardium. Alterations in cardiac ECM structure associated with heart failure influence cell-matrix and cell-cell adhesions modifying cell shape and mechanotransduction.
The need to understand the cardiac ECM remodelling mechanisms that allow us to identify new therapeutic targets lead us to create biomimetic scaffolds which emulate the structure, topography, mechanics and chemical composition of ECM.
Here, we present the development of modulable materials for the manufacturing, by using photopolymerizable materials, of structured hydrogels with myocardium properties of stiffness and elastic modulus in physiological and pathological conditions.
000121450 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000121450 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121450 700__ $$aBelaza, Andrés
000121450 700__ $$aVigueras, Alan
000121450 700__ $$0(orcid)0000-0003-3660-8651$$aVirumbrales, María
000121450 700__ $$0(orcid)0000-0002-5731-8840$$aLlamazares, Guillermo
000121450 700__ $$0(orcid)0000-0003-0641-3407$$aAsín, Laura$$uUniversidad de Zaragoza
000121450 700__ $$0(orcid)0000-0003-1081-8482$$aDe la Fuente, Jesús M.
000121450 700__ $$0(orcid)0000-0001-9972-0902$$aMedel, Francisco$$uUniversidad de Zaragoza
000121450 700__ $$0(orcid)0000-0003-0088-7222$$aDoweidar, Mohamed H.$$uUniversidad de Zaragoza
000121450 700__ $$0(orcid)0000-0003-0156-4230$$aOliván, Sara$$uUniversidad de Zaragoza
000121450 700__ $$0(orcid)0000-0001-5376-4440$$aFernández Ledesma, Luis$$uUniversidad de Zaragoza
000121450 700__ $$0(orcid)0000-0001-8741-6452$$aDoblaré, Manuel$$uUniversidad de Zaragoza
000121450 700__ $$aGonzález Miqueo, Arantxa
000121450 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, Iñaki$$uUniversidad de Zaragoza
000121450 700__ $$0(orcid)0000-0003-3900-2866$$aSánchez-Somolinos, Carlos$$uUniversidad de Zaragoza
000121450 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000121450 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000121450 7102_ $$15004$$2545$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Ingeniería Mecánica
000121450 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000121450 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000121450 773__ $$g5 (2019), [2 pp.]$$pJorn. jóvenes investig. I3A$$tJornada de jóvenes investigadores del I3A$$x2341-4790
000121450 8564_ $$s277696$$uhttps://zaguan.unizar.es/record/121450/files/texto_completo.pdf$$yVersión publicada
000121450 8564_ $$s2872836$$uhttps://zaguan.unizar.es/record/121450/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121450 909CO $$ooai:zaguan.unizar.es:121450$$particulos$$pdriver
000121450 951__ $$a2023-01-26-09:33:05
000121450 980__ $$aARTICLE