121450 20230126110117.0 doi 10.26754/jji-i3a.201711983 sideral 131938 ART-2019-131938 eng González Lana, Sandra New Structured Materials in the Study of the Mechanobiological Processes Related to the Heart Failure 2019 Cardiovascular diseases are the number one of death globally. According to the World Health organization 17.7 million people died from cardiovascular diseases in 2015, representing 31% of all global deaths. In these diseases the cardiac homeostasis is disrupted by a non-appropriate myocardium remodelling. The cardiac extracellular matrix (ECM) provides not only the biochemical environment but also a natural scaffold surrounding and connecting cardiac cells and distributing mechanical forces throughout the organ. Thus, the properties of the ECM are essential for the maintenance of the functional myocardium. Alterations in cardiac ECM structure associated with heart failure influence cell-matrix and cell-cell adhesions modifying cell shape and mechanotransduction. The need to understand the cardiac ECM remodelling mechanisms that allow us to identify new therapeutic targets lead us to create biomimetic scaffolds which emulate the structure, topography, mechanics and chemical composition of ECM. Here, we present the development of modulable materials for the manufacturing, by using photopolymerizable materials, of structured hydrogels with myocardium properties of stiffness and elastic modulus in physiological and pathological conditions. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Belaza, Andrés Vigueras, Alan Virumbrales, María (orcid)0000-0003-3660-8651 Llamazares, Guillermo (orcid)0000-0002-5731-8840 Asín, Laura Universidad de Zaragoza (orcid)0000-0003-0641-3407 De la Fuente, Jesús M. (orcid)0000-0003-1081-8482 Medel, Francisco Universidad de Zaragoza (orcid)0000-0001-9972-0902 Doweidar, Mohamed H. Universidad de Zaragoza (orcid)0000-0003-0088-7222 Oliván, Sara Universidad de Zaragoza (orcid)0000-0003-0156-4230 Fernández Ledesma, Luis Universidad de Zaragoza (orcid)0000-0001-5376-4440 Doblaré, Manuel Universidad de Zaragoza (orcid)0000-0001-8741-6452 González Miqueo, Arantxa Ochoa, Iñaki Universidad de Zaragoza (orcid)0000-0003-2410-5678 Sánchez-Somolinos, Carlos Universidad de Zaragoza (orcid)0000-0003-3900-2866 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 5004 545 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Ingeniería Mecánica 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 5 (2019), [2 pp.] Jorn. jóvenes investig. I3A Jornada de jóvenes investigadores del I3A 2341-4790 277696 http://zaguan.unizar.es/record/121450/files/texto_completo.pdf Versión publicada 2872836 http://zaguan.unizar.es/record/121450/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121450 articulos driver 2023-01-26-09:33:05 ARTICLE