000121611 001__ 121611
000121611 005__ 20241125101128.0
000121611 0247_ $$2doi$$a10.3390/cancers15030616
000121611 0248_ $$2sideral$$a132185
000121611 037__ $$aART-2023-132185
000121611 041__ $$aeng
000121611 100__ $$0(orcid)0000-0003-0178-4567$$aBorque-Fernando, Ángel$$uUniversidad de Zaragoza
000121611 245__ $$aEpidemiology, Diagnosis and Management of Penile Cancer: Results from the Spanish National Registry of Penile Cancer
000121611 260__ $$c2023
000121611 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121611 5203_ $$aIntroduction: Penile cancer (PC) is a rare malignancy with an overall incidence in Europe of 1/100,000 males/year. In Europe, few studies report the epidemiology, risk factors, clinical presentation, and treatment of PC. The aim of this study is to present an updated outlook on the aforementioned factors of PC in Spain. Materials and Methods: A multicentric, retrospective, observational epidemiological study was designed, and patients with a new diagnosis of PC in 2015 were included. Patients were anonymously identified from the Register of Specialized Care Activity of the Ministry of Health of Spain. All Spanish hospitals recruiting patients in 2015 were invited to participate in the present study. We have followed a descriptive narration of the observed data. Continuous and categorical data were reported by median (p25th–p75th range) and absolute and relative frequencies, respectively. The incidence map shows differences between Spanish regions. Results: The incidence of PC in Spain in 2015 was 2.55/100,000 males per year. A total of 586 patients were identified, and 228 patients from 61 hospitals were included in the analysis. A total of 54/61 (88.5%) centers reported ≤ 5 new cases. The patients accessed the urologist for visually-assessed penile lesions (60.5%), mainly localized in the glans (63.6%). Local hygiene, smoking habits, sexual habits, HPV exposure, and history of penile lesions were reported in 48.2%, 59.6%, 25%, 13.2%, and 69.7%. HPV-positive lesions were 18.1% (28.6% HPV-16). The majority of PC was squamous carcinoma (95.2%). PC was ≥cT2 in 45.2% (103/228) cases. At final pathology, PC was ≥pT2 in 51% of patients and ≥pN1 in 17% of cases. The most common local treatment was partial penectomy (46.9% cases). A total of 47/55 (85.5%) inguinal lymphadenectomies were open. Patients with ≥pN1 disease were treated with chemotherapy in 12/39 (40.8%) of cases. Conclusions: PC incidence is relatively high in Spain compared to other European countries. The risk factors for PC are usually misreported. The diagnosis and management of PC are suboptimal, encouraging the identification of referral centers for PC management.
000121611 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-116873GB-I00
000121611 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121611 590__ $$a4.5$$b2023
000121611 592__ $$a1.391$$b2023
000121611 591__ $$aONCOLOGY$$b78 / 322 = 0.242$$c2023$$dQ1$$eT1
000121611 593__ $$aOncology$$c2023$$dQ1
000121611 593__ $$aCancer Research$$c2023$$dQ2
000121611 594__ $$a8.0$$b2023
000121611 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121611 700__ $$aGaya, Josep Maria
000121611 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban-Escaño, Luis Mariano
000121611 700__ $$aGómez-Rivas, Juan
000121611 700__ $$aGarcía-Baquero, Rodrigo
000121611 700__ $$aAgreda-Castañeda, Fernando
000121611 700__ $$aGallioli, Andrea
000121611 700__ $$aVerri, Paolo
000121611 700__ $$aOrtiz-Vico, Francisco Javier
000121611 700__ $$aAmir-Nicolau, Balig Fawwaz
000121611 700__ $$aOsman-Garcia, Ignacio
000121611 700__ $$0(orcid)0000-0002-7722-6871$$aGil-Martínez, Pedro$$uUniversidad de Zaragoza
000121611 700__ $$aArrabal-Martín, Miguel
000121611 700__ $$aGómez-Ferrer Lozano, Álvaro
000121611 700__ $$aCampos-Juanatey, Felix
000121611 700__ $$aGuerrero-Ramos, Félix
000121611 700__ $$aRubio-Briones, José
000121611 7102_ $$11013$$2817$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Urología
000121611 773__ $$g15, 3 (2023), 616 [12 pp.]$$pCancers$$tCancers$$x2072-6694
000121611 8564_ $$s963176$$uhttps://zaguan.unizar.es/record/121611/files/texto_completo.pdf$$yVersión publicada
000121611 8564_ $$s2861326$$uhttps://zaguan.unizar.es/record/121611/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121611 909CO $$ooai:zaguan.unizar.es:121611$$particulos$$pdriver
000121611 951__ $$a2024-11-22-11:58:14
000121611 980__ $$aARTICLE