121611 20241125101128.0 doi 10.3390/cancers15030616 sideral 132185 ART-2023-132185 eng Borque-Fernando, Ángel Universidad de Zaragoza (orcid)0000-0003-0178-4567 Epidemiology, Diagnosis and Management of Penile Cancer: Results from the Spanish National Registry of Penile Cancer 2023 Access copy available to the general public Unrestricted Introduction: Penile cancer (PC) is a rare malignancy with an overall incidence in Europe of 1/100,000 males/year. In Europe, few studies report the epidemiology, risk factors, clinical presentation, and treatment of PC. The aim of this study is to present an updated outlook on the aforementioned factors of PC in Spain. Materials and Methods: A multicentric, retrospective, observational epidemiological study was designed, and patients with a new diagnosis of PC in 2015 were included. Patients were anonymously identified from the Register of Specialized Care Activity of the Ministry of Health of Spain. All Spanish hospitals recruiting patients in 2015 were invited to participate in the present study. We have followed a descriptive narration of the observed data. Continuous and categorical data were reported by median (p25th–p75th range) and absolute and relative frequencies, respectively. The incidence map shows differences between Spanish regions. Results: The incidence of PC in Spain in 2015 was 2.55/100,000 males per year. A total of 586 patients were identified, and 228 patients from 61 hospitals were included in the analysis. A total of 54/61 (88.5%) centers reported ≤ 5 new cases. The patients accessed the urologist for visually-assessed penile lesions (60.5%), mainly localized in the glans (63.6%). Local hygiene, smoking habits, sexual habits, HPV exposure, and history of penile lesions were reported in 48.2%, 59.6%, 25%, 13.2%, and 69.7%. HPV-positive lesions were 18.1% (28.6% HPV-16). The majority of PC was squamous carcinoma (95.2%). PC was ≥cT2 in 45.2% (103/228) cases. At final pathology, PC was ≥pT2 in 51% of patients and ≥pN1 in 17% of cases. The most common local treatment was partial penectomy (46.9% cases). A total of 47/55 (85.5%) inguinal lymphadenectomies were open. Patients with ≥pN1 disease were treated with chemotherapy in 12/39 (40.8%) of cases. Conclusions: PC incidence is relatively high in Spain compared to other European countries. The risk factors for PC are usually misreported. The diagnosis and management of PC are suboptimal, encouraging the identification of referral centers for PC management. info:eu-repo/grantAgreement/ES/MICINN/PID2020-116873GB-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.5 2023 ONCOLOGY 78 / 322 = 0.242 2023 Q1 T1 1.391 2023 Oncology 2023 Q1 Cancer Research 2023 Q2 8.0 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gaya, Josep Maria Esteban-Escaño, Luis Mariano (orcid)0000-0002-3007-302X Gómez-Rivas, Juan García-Baquero, Rodrigo Agreda-Castañeda, Fernando Gallioli, Andrea Verri, Paolo Ortiz-Vico, Francisco Javier Amir-Nicolau, Balig Fawwaz Osman-Garcia, Ignacio Gil-Martínez, Pedro Universidad de Zaragoza (orcid)0000-0002-7722-6871 Arrabal-Martín, Miguel Gómez-Ferrer Lozano, Álvaro Campos-Juanatey, Felix Guerrero-Ramos, Félix Rubio-Briones, José 1013 817 Universidad de Zaragoza Dpto. Cirugía Área Urología 15, 3 (2023), 616 [12 pp.] Cancers Cancers 2072-6694 963176 http://zaguan.unizar.es/record/121611/files/texto_completo.pdf Versión publicada 2861326 http://zaguan.unizar.es/record/121611/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121611 articulos driver 2024-11-22-11:58:14 ARTICLE