121612 20241125101128.0 doi 10.3390/cancers15030721 sideral 132184 ART-2023-132184 eng Hijos-Mallada, Gonzalo Universidad de Zaragoza A Point-of-Care Faecal Test Combining Four Biomarkers Allows Avoidance of Normal Colonoscopies and Prioritizes Symptomatic Patients with a High Risk of Colorectal Cancer 2023 Access copy available to the general public Unrestricted Most colonoscopies performed to evaluate gastrointestinal symptoms detect only non-relevant pathologies. We aimed to evaluate the diagnostic accuracy of a qualitative point-of-care (POC) test combining four biomarkers (haemoglobin, transferrin, calprotectin, and lactoferrin), a quantitative faecal immunochemical test (FIT) for haemoglobin, and a quantitative faecal calprotectin (FC) test in symptomatic patients prospectively recruited. Colorectal cancer (CRC), adenoma requiring surveillance, inflammatory bowel disease (IBD), microscopic colitis, and angiodysplasia were considered significant pathologies. A total of 571 patients were included. Significant pathology was diagnosed in 118 (20.7%), including 30 CRC cases (5.3%). The POC test yielded the highest negative predictive values: 94.8% for a significant pathology and 100% for CRC or IBD if the four markers turned negative (36.8% of the patients). Negative predictive values of FIT, FC, and its combination for diagnosis of a significant pathology were 88.4%, 87.6%, and 90.8%, respectively. Moreover, the positive predictive value using the POC test was 82.3% for significant pathology when all biomarkers tested positive (6% of the patients), with 70.6% of these patients diagnosed with CRC or IBD. The AUC of the POC test was 0.801 (95%CI 0.754-0.848) for the diagnosis of a significant pathology. Therefore, this POC faecal test allows the avoidance of unnecessary colonoscopies and prioritizes high risk symptomatic patients. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.5 2023 ONCOLOGY 78 / 322 = 0.242 2023 Q1 T1 1.391 2023 Oncology 2023 Q1 Cancer Research 2023 Q2 8.0 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Saura, Nuria Lué, Alberto Universidad de Zaragoza Velamazan, Raúl Nieto, Rocío Navarro, Mercedes Arechavaleta, Samantha Chueca, Eduardo Gomollon, Fernando Universidad de Zaragoza (orcid)0000-0003-0076-3529 Lanas, Angel Universidad de Zaragoza (orcid)0000-0001-5932-2889 Sostres, Carlos 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 15, 3 (2023), 721 [14 pp.] Cancers Cancers 2072-6694 880641 http://zaguan.unizar.es/record/121612/files/texto_completo.pdf Versión publicada 2664641 http://zaguan.unizar.es/record/121612/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121612 articulos driver 2024-11-22-11:58:15 ARTICLE