000121876 001__ 121876
000121876 005__ 20241125101129.0
000121876 0247_ $$2doi$$a10.3390/math11040829
000121876 0248_ $$2sideral$$a132319
000121876 037__ $$aART-2023-132319
000121876 041__ $$aeng
000121876 100__ $$0(orcid)0000-0002-2360-8276$$aHernández-López, Patricia$$uUniversidad de Zaragoza
000121876 245__ $$aUnderstanding the Parameter Influence on Lesion Growth for a Mechanobiology Model of Atherosclerosis
000121876 260__ $$c2023
000121876 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121876 5203_ $$aIn this work, we analyse the influence of the parameters of a mathematical model, previously proposed by the authors, for reproducing atheroma plaque in arteries. The model uses Navier–Stokes equations to calculate the blood flow along the lumen in a transient mode. It also uses Darcy’s law, Kedem–Katchalsky equations, and the three-pore model to simulate plasma and substance flows across the endothelium. The behaviours of all substances in the arterial wall are modelled with convection–diffusion–reaction equations, and finally, plaque growth is calculated. We consider a 2D geometry of a carotid artery, but the model can be extrapolated to other geometries or arteries, such as the coronaries or the aorta. A mono-variant sensitivity analysis of the model parameters was performed, with values of ±25% and ±10%, with respect to the values of the previous model. The results were analysed with respect to the volume in the plaque of foam cells (FC), synthetic smooth muscle cells (SSMC), and collagen fibre. It was observed that the volume in the plaque of the different substances (FC, SSMC, and collagen) has a strong influence on the results, so it could be used to analyse the vulnerability of plaque. The stenosis ratio of the plaque was also analysed, showing a strong influence on the results as well. Parameters that influence all the results considered when ranged ±10% are the rate of LDL degradation and the diffusion coefficients of LDL and monocytes in the arterial wall. Furthermore, it was observed that the change in the volume of foam cells in the plaque has a greater influence on the stenosis ratio than the change of synthetic smooth muscle cells or collagen fibre.
000121876 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R$$9info:eu-repo/grantAgreement/ES/MICINN/BES-2017-080239$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-107517RB-I00
000121876 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121876 590__ $$a2.3$$b2023
000121876 592__ $$a0.475$$b2023
000121876 591__ $$aMATHEMATICS$$b21 / 490 = 0.043$$c2023$$dQ1$$eT1
000121876 593__ $$aEngineering (miscellaneous)$$c2023$$dQ2
000121876 593__ $$aMathematics (miscellaneous)$$c2023$$dQ2
000121876 593__ $$aComputer Science (miscellaneous)$$c2023$$dQ2
000121876 594__ $$a4.0$$b2023
000121876 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121876 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, Miguel A.$$uUniversidad de Zaragoza
000121876 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, Estefanía$$uUniversidad de Zaragoza
000121876 700__ $$0(orcid)0000-0002-8503-9291$$aCilla, Myriam$$uUniversidad de Zaragoza
000121876 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000121876 773__ $$g11, 4 (2023), 829 [25 pp.]$$pMathematics (Basel)$$tMathematics$$x2227-7390
000121876 8564_ $$s860878$$uhttps://zaguan.unizar.es/record/121876/files/texto_completo.pdf$$yVersión publicada
000121876 8564_ $$s2573866$$uhttps://zaguan.unizar.es/record/121876/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121876 909CO $$ooai:zaguan.unizar.es:121876$$particulos$$pdriver
000121876 951__ $$a2024-11-22-11:58:25
000121876 980__ $$aARTICLE