000012274 001__ 12274 000012274 005__ 20170831220510.0 000012274 037__ $$aTAZ-TFM-2013-786 000012274 041__ $$aeng 000012274 1001_ $$aHerrer Jiménez, Isabel Lucía 000012274 24500 $$aThermosensitive and photopolymerizable hydrogels based on Pluronic F127 000012274 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2013 000012274 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/ 000012274 520__ $$aHere it is reported the design, synthesis and characterization of new Pluronic® F127 derivatives, with the ability to form thermosensitive and photopolymerizable hydrogels. These active hydrogels undergo a sol-to-gel transition by increasing the temperature in a physiologically important temperature range thus resulting attractive for biomedical applications and drug delivery systems. Pluronic® F127 has been functionalized with photoreactive groups and the obtained derivatives and their precursors have been fully characterized by conventional techniques. Then the aimed compounds have been processed as macroscopically molded hydrogels and as nanostructured hydrogels (nanogels). A highly crosslinked internal structure has been reached by the photopolymerization technique for the thermosensitive macroscopic hydrogels designed to act as cell scaffolds for cartilage repair. Swelling and degradation studies as well as their morphological characterization by SEM have been carried out. Concerning the nanostructured hydrogels (nanogels), after determining its critical micellar concentration and applying a photopolymerization process to fix the nanostructure, they have been characterized by TEM, SEM and DLS. Cell viability assays have been carried out for both types of system, the macroscopic hydrogel and the nanogel. 000012274 521__ $$aMáster Universitario en Materiales Nanoestructurados para Aplicaciones Nanotecnológicas (Nanostructured Materials for Nanotechnology Applications) 000012274 540__ $$aDerechos regulados por licencia Creative Commons 000012274 700__ $$aRos Latienda, Blanca$$edir. 000012274 700__ $$aSierra Travieso, Teresa$$edir. 000012274 7102_ $$aUniversidad de Zaragoza$$b $$c 000012274 8560_ $$f525061@celes.unizar.es 000012274 8564_ $$s5819385$$uhttps://zaguan.unizar.es/record/12274/files/TAZ-TFM-2013-786.pdf$$yMemoria (eng)$$zMemoria (eng) 000012274 909CO $$ooai:zaguan.unizar.es:12274$$ptrabajos-fin-master$$pdriver 000012274 950__ $$a 000012274 980__ $$aTAZ$$bTFM$$cCIEN