123894 20240319081028.0 doi 10.3389/fendo.2022.1082684 sideral 132334 ART-2022-132334 eng de Lamas, Carmela Progression of metabolic syndrome and associated cardiometabolic risk factors from prepuberty to puberty in children: The PUBMEP study 2022 Access copy available to the general public Unrestricted IntroductionMetabolic syndrome (MetS) is a cluster of clinical and metabolic alterations related to the risk of cardiovascular diseases (CVD). Metabolic changes occurring during puberty, especially in children with overweight and obesity, can influence the risk of developing chronic diseases, especially CVD.MethodsLongitudinal study based on the follow-up until puberty of a cohort of 191 prepubertal Spanish boys and girls without congenital, chronic, or inflammatory diseases: undernutrition: or intake of any drug that could alter blood glucose, blood pressure, or lipid metabolism. The following parameters were used to determine the presence of MetS: obesity, hypertension, hyperglycemia, hypertriglyceridemia, and low HDL-c.ResultsA total of 75·5% of participants stayed in the same BMI category from prepuberty to puberty, whereas 6·3% increased by at least one category. The prevalence of MetS was 9·1% (prepubertal stage) and 11·9% (pubertal stage). The risk of presenting alterations in puberty for systolic blood pressure (SBP), plasma triacylglycerols, HDL cholesterol (HDL-c), and HOMA-IR was significantly higher in those participants who had the same alterations in prepuberty. MetS prevalence in puberty was predicted by sex and levels of HOMA-IR, BMI-z, and waist circumference in the prepubertal stage, in the whole sample: in puberty, the predictors were levels of HOMA-IR, BMI-z, and diastolic blood pressure in participants with obesity. Two fast-and-frugal decision trees were built to predict the risk of MetS in puberty based on prepuberty HOMA-IR (cutoff 2·5), SBP (cutoff 106 mm of Hg), and TAG (cutoff 53 mg/dl).DiscussionControlling obesity and cardiometabolic risk factors, especially HOMA-IR and blood pressure, in children during the prepubertal stage appears critical to preventing pubertal MetS effectively. info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043 info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI05-1968 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00563 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00924 info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048 info:eu-repo/grantAgreement/ES/ISCIII/PI20-00988 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.2 2022 ENDOCRINOLOGY & METABOLISM 36 / 144 = 0.25 2022 Q1 T1 1.278 2022 Endocrinology, Diabetes and Metabolism 2022 Q1 5.6 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Kalén, Anton Anguita-Ruiz, Augusto Pérez-Ferreirós, Alexandra Picáns-Leis, Rosaura Flores, Katherine Moreno, Luis A. Universidad de Zaragoza (orcid)0000-0003-0454-653X Bueno, Gloria Universidad de Zaragoza (orcid)0000-0002-0902-387X Gil, Ángel Gil-Campos, Mercedes Aguilera, Concepción M. Leis, Rosaura 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 13 (2022), [14 pp.] Front. endocrinol. Frontiers in Endocrinology 1664-2392 2312610 http://zaguan.unizar.es/record/123894/files/texto_completo.pdf Versión publicada 2343105 http://zaguan.unizar.es/record/123894/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:123894 articulos driver 2024-03-18-16:59:21 ARTICLE