000123975 001__ 123975
000123975 005__ 20231108202304.0
000123975 0247_ $$2doi$$a10.1016/j.envpol.2022.120773
000123975 0248_ $$2sideral$$a132532
000123975 037__ $$aART-2023-132532
000123975 041__ $$aeng
000123975 100__ $$aNagrani, Rajini
000123975 245__ $$aAssociation of urinary and ambient black carbon, and other ambient air pollutants with risk of prediabetes and metabolic syndrome in children and adolescents
000123975 260__ $$c2023
000123975 5060_ $$aAccess copy available to the general public$$fUnrestricted
000123975 5203_ $$aThe effects of exposure to black carbon (BC) on various diseases remains unclear, one reason being potential exposure misclassification following modelling of ambient air pollution levels. Urinary BC particles may be a more precise measure to analyze the health effects of BC. We aimed to assess the risk of prediabetes and metabolic syndrome (MetS) in relation to urinary BC particles and ambient BC and to compare their associations in 5453 children from IDEFICS/I. Family cohort. We determined the amount of BC particles in urine using label-free white-light generation under femtosecond pulsed laser illumination. We assessed annual exposure to ambient air pollutants (BC, PM2.5 and NO2) at the place of residence using land use regression models for Europe, and we calculated the residential distance to major roads (≤250 m vs. more). We analyzed the cross-sectional relationships between urinary BC and air pollutants (BC, PM2.5 and NO2) and distance to roads, and the associations of all these variables to the risk of prediabetes and MetS, using logistic and linear regression models. Though we did not observe associations between urinary and ambient BC in overall analysis, we observed a positive association between urinary and ambient BC levels in boys and in children living ≤250 m to a major road compared to those living >250 m away from a major road. We observed a positive association between log-transformed urinary BC particles and MetS (ORper unit increase = 1.72, 95% CI = 1.21; 2.45). An association between ambient BC and MetS was only observed in children living closer to a major road. Our findings suggest that exposure to BC (ambient and biomarker) may contribute to the risk of MetS in children. By measuring the internal dose, the BC particles in urine may have additionally captured non-residential sources and reduced exposure misclassification. Larger studies, with longitudinal design including measurement of urinary BC at multiple time-points are warranted to confirm our findings.
000123975 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000123975 590__ $$a8.9$$b2022
000123975 592__ $$a2.11$$b2022
000123975 591__ $$aENVIRONMENTAL SCIENCES$$b28 / 274 = 0.102$$c2022$$dQ1$$eT1
000123975 593__ $$aHealth, Toxicology and Mutagenesis$$c2022$$dQ1
000123975 593__ $$aToxicology$$c2022$$dQ1
000123975 593__ $$aPollution$$c2022$$dQ1
000123975 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000123975 594__ $$a14.9$$b2022
000123975 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000123975 700__ $$aMarron, Manuela
000123975 700__ $$aBongaerts, Eva
000123975 700__ $$aNawrot, Tim S.
000123975 700__ $$aAmeloot, Marcel
000123975 700__ $$ade Hoogh, Kees
000123975 700__ $$aVienneau, Danielle
000123975 700__ $$aLequy, Emeline
000123975 700__ $$aJacquemin, Bénédicte
000123975 700__ $$aGuenther, Kathrin
000123975 700__ $$aDe Ruyter, Thaïs
000123975 700__ $$aMehlig, Kirsten
000123975 700__ $$aMolnár, Dénes
000123975 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000123975 700__ $$aRusso, Paola
000123975 700__ $$aVeidebaum, Toomas
000123975 700__ $$aAhrens, Wolfgang
000123975 700__ $$aBuck, Christoph
000123975 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000123975 773__ $$g317 (2023), 120773 [12 pp.]$$pEnviron. pollut.$$tEnvironmental Pollution$$x0269-7491
000123975 8564_ $$s1971276$$uhttps://zaguan.unizar.es/record/123975/files/texto_completo.pdf$$yVersión publicada
000123975 8564_ $$s2398311$$uhttps://zaguan.unizar.es/record/123975/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000123975 909CO $$ooai:zaguan.unizar.es:123975$$particulos$$pdriver
000123975 951__ $$a2023-11-08-20:19:35
000123975 980__ $$aARTICLE