000123983 001__ 123983
000123983 005__ 20241125101129.0
000123983 0247_ $$2doi$$a10.1007/s12519-022-00665-8
000123983 0248_ $$2sideral$$a132558
000123983 037__ $$aART-2023-132558
000123983 041__ $$aeng
000123983 100__ $$aRuiz-Ojeda, Francisco Javier
000123983 245__ $$aSerum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys
000123983 260__ $$c2023
000123983 5060_ $$aAccess copy available to the general public$$fUnrestricted
000123983 5203_ $$aObjectives: To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1 (ISM1) and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with obesity. Methods: The study population is a sub-cohort of the PUBMEP research project, consisting of a cross-sectional population of 119 pubertal children with overweight (17 boys, 19 girls), obesity (20 boys, 25 girls), and normal weight (17 boys, 21 girls). All subjects were classified into experimental groups according to their sex, obesity, and insulin resistance (IR) status. They were counted anthropometry, glucose and lipid metabolism, inflammation and cardiovascular biomarkers as well as isthmin-1 (ISM1) serum levels. This population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in children. Furthermore, the study population had blood whole-genome DNA methylation examined, allowing deepening into the obesity–ISM1 molecular relationship. Results: Higher serum ISM1 levels were observed in boys with obesity than in normal weight (P = 0.004) and overweight (P = 0.007) boys. ISM1 serum levels were positively associated with body mass index (BMI) Z-score (P = 0.005) and fat mass (P = 0.058) and negatively associated with myeloperoxidase (MPO) (P = 0.043) in boys. Although we did not find associations between ISM1 serum levels and metabolic outcomes in girls, which may indicate a putative sexual dimorphism, fat mass was positively associated in all children, including boys and girls (P = 0.011). DNA methylation levels in two-enhancer-related CpG sites of ISM1 (cg03304641 and cg14269097) were associated with serum levels of ISM1 in children. Conclusions: ISM1 is associated with obesity in boys at the pubertal stage, elucidating how this protein might be of special relevance as a new biomarker of obesity in children. Further studies including a longitudinal design during puberty are needed.
000123983 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI051968$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI1102042$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI1600871$$9info:eu-repo/grantAgreement/ES/MSCBS-ISCIII-FEDER/RETICS-RD12-0026-0015
000123983 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000123983 590__ $$a3.6$$b2023
000123983 592__ $$a0.91$$b2023
000123983 591__ $$aPEDIATRICS$$b17 / 186 = 0.091$$c2023$$dQ1$$eT1
000123983 593__ $$aPediatrics, Perinatology and Child Health$$c2023$$dQ1
000123983 594__ $$a10.5$$b2023
000123983 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000123983 700__ $$aAnguita-Ruiz, Augusto
000123983 700__ $$aRico, Maria C.
000123983 700__ $$aLeis, Rosaura
000123983 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, Gloria$$uUniversidad de Zaragoza
000123983 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000123983 700__ $$aGil-Campos, Mercedes
000123983 700__ $$aGil, Ángel
000123983 700__ $$aAguilera, Concepción M.
000123983 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000123983 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000123983 773__ $$g19, 9 (2023), 864–872$$pWorld Journal of Pediatrics$$tWorld Journal of Pediatrics$$x1708-8569
000123983 8564_ $$s1050285$$uhttps://zaguan.unizar.es/record/123983/files/texto_completo.pdf$$yVersión publicada
000123983 8564_ $$s2565705$$uhttps://zaguan.unizar.es/record/123983/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000123983 909CO $$ooai:zaguan.unizar.es:123983$$particulos$$pdriver
000123983 951__ $$a2024-11-22-11:58:28
000123983 980__ $$aARTICLE