doi:10.1192/bjp.2022.178engLópez-Bueno, RubénCalatayud, J.Andersen, L.L.Casaña, J.Koyanagi, A.Del Pozo Cruz, B.Smith, L.Dose–response association of handgrip strength and risk of depression: a longitudinal study of 115 601 older adults from 24 countriesART-2023-132586Background: Prior research has solely focused on the association between handgrip strength and risk of depression in single countries or general populations, but more knowledge is required from wider-spread cohorts and target populations. Aims: This study aimed to investigate the association between handgrip strength and risk of depression using repeated measures in adults aged 50 years and over. Method: Data on handgrip strength and risk of depression were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7, using a hand dynamometer (Smedley, S Dynamometer, TTM) and the EURO-D 12-item scale, respectively. Time-varying exposure and covariates were modelled using both Cox regression and restricted cubic splines. Results: A total of 115 601 participants (mean age 64.3 years (s.d. = 9.9), 54.3% women) were followed-up for a median of 7.3 years (interquartile range: 3.9–11.8) and 792 459 person-years. During this period, 30 208 (26.1%) participants experienced a risk of depression. When modelled as a continuous variable, we observed an inverse significant association for each kg increase of handgrip strength and depression up to 40 kg in men and up to 27 kg in women. Conclusions: Being physically strong may serve as a preventive factor for depression in older adults, but this is limited up to a maximum specific threshold for men and women.2023http://zaguan.unizar.es/record/12398810.1192/bjp.2022.178http://zaguan.unizar.es/record/123988oai:zaguan.unizar.es:123988info:eu-repo/grantAgreement/EC/FP6/28812/EU/Employment and health at 50+: a life history approach to european welfare state interventions/SHARELIFEinfo:eu-repo/grantAgreement/EC/FP6/28857/EU/Toolbox for Improving the Comparability of Cross-National Survey Data with Applications to SHARE/COMPAREinfo:eu-repo/grantAgreement/EC/FP6/62193/EU/Survey of Health, Ageing and Retirement in Europe: Integrating Activities to Access the Time Dimension and to Enlarge the Cross-national Dimension/SHARE-I3info:eu-repo/grantAgreement/EC/FP7/211909/EU/Upgrading the Survey of Health, Ageing and Retirement in Europe – preparatory phase/SHARE-PREPinfo:eu-repo/grantAgreement/EC/FP7/227822/EU/Longitudinal Enhancement and Access imProvement of the SHARE infrastructure/SHARE_LEAPinfo:eu-repo/grantAgreement/EC/FP7/261982/EU/Multinational Advancement of Research Infrastructures on Ageing/SHARE_M4info:eu-repo/grantAgreement/EC/FP7/283646/EU/Data Service Infrastructure for the Social Sciences and Humanities/DASISHinfo:eu-repo/grantAgreement/EC/HS/QLK6-CT-2001-00360/EU/Survey on health, ageing and retirement in europe (SHARE)/SHAREinfo:eu-repo/grantAgreement/EC/H2020/654221/EU/Synergies for Europe's Research Infrastructures in the Social Sciences/SERISSThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 654221-SERISSinfo:eu-repo/grantAgreement/EC/H2020/676536/EU/Achieving world-class standards in all SHARE countries/SHARE-DEV3This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 676536-SHARE-DEV3info:eu-repo/grantAgreement/EC/H2020/823782/EU/Social Sciences & Humanities Open Cloud/SSHOCThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823782-SSHOCinfo:eu-repo/grantAgreement/EC/H2020/870628/EU/Cohesion in further developing and innovating SHARE across all 28 member countries/SHARE-COHESIONThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 870628-SHARE-COHESIONBRITISH JOURNAL OF PSYCHIATRY 222, 3 (2023), 135-142byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess