000124000 001__ 124000
000124000 005__ 20240319081028.0
000124000 0247_ $$2doi$$a10.1186/s12951-022-01747-5
000124000 0248_ $$2sideral$$a132560
000124000 037__ $$aART-2022-132560
000124000 041__ $$aeng
000124000 100__ $$aPortilla, Y.
000124000 245__ $$aDifferent coatings on magnetic nanoparticles dictate their degradation kinetics in vivo for 15 months after intravenous administration in mice
000124000 260__ $$c2022
000124000 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124000 5203_ $$aBackground: The surface coating of iron oxide magnetic nanoparticle (MNPs) drives their intracellular trafficking and degradation in endolysosomes, as well as dictating other cellular outcomes. As such, we assessed whether MNP coatings might influence their biodistribution, their accumulation in certain organs and their turnover therein, processes that must be understood in vivo to optimize the design of nanoformulations for specific therapeutic/diagnostic needs. Results: In this study, three different MNP coatings were analyzed, each conferring the identical 12 nm iron oxide cores with different physicochemical characteristics: 3-aminopropyl-triethoxysilane (APS), dextran (DEX), and dimercaptosuccinic acid (DMSA). When the biodistribution of these MNPs was analyzed in C57BL/6 mice, they all mainly accumulated in the spleen and liver one week after administration. The coating influenced the proportion of the MNPs in each organ, with more APS-MNPs accumulating in the spleen and more DMSA-MNPs accumulating in the liver, remaining there until they were fully degraded. The changes in the physicochemical properties of the MNPs (core size and magnetic properties) was also assessed during their intracellular degradation when internalized by two murine macrophage cell lines. The decrease in the size of the MNPs iron core was influenced by their coating and the organ in which they accumulated. Finally, MNP degradation was analyzed in the liver and spleen of C57BL/6 mice from 7 days to 15 months after the last intravenous MNP administration. Conclusions: The MNPs degraded at different rates depending on the organ and their coating, the former representing the feature that was fundamental in determining the time they persisted. In the liver, the rate of degradation was similar for all three coatings, and it was faster than in the spleen. This information regarding the influence of coatings on the in vivo degradation of MNPs will help to choose the best coating for each biomedical application depending on the specific clinical requirements.
000124000 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-112685RB-I00$$9info:eu-repo/grantAgreement/ES/AEI/SAF2017-82223-R$$9info:eu-repo/grantAgreement/ES/MECD/FPU15-06170$$9info:eu-repo/grantAgreement/ES/MINECO/IJCI-2017-31447$$9info:eu-repo/grantAgreement/ES/MINECO/PGC2018-096016-B-I00
000124000 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000124000 590__ $$a10.2$$b2022
000124000 592__ $$a1.421$$b2022
000124000 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b21 / 107 = 0.196$$c2022$$dQ1$$eT1
000124000 593__ $$aApplied Microbiology and Biotechnology$$c2022$$dQ1
000124000 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b12 / 158 = 0.076$$c2022$$dQ1$$eT1
000124000 593__ $$aBioengineering$$c2022$$dQ1
000124000 593__ $$aBiomedical Engineering$$c2022$$dQ1
000124000 593__ $$aPharmaceutical Science$$c2022$$dQ1
000124000 593__ $$aMolecular Medicine$$c2022$$dQ1
000124000 593__ $$aNanoscience and Nanotechnology$$c2022$$dQ1
000124000 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000124000 594__ $$a10.0$$b2022
000124000 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124000 700__ $$0(orcid)0000-0002-0970-1917$$aFernández-Afonso, Y.
000124000 700__ $$aPérez-Yagüe, S.
000124000 700__ $$aMulens-Arias, V.
000124000 700__ $$aMorales, M. P.
000124000 700__ $$0(orcid)0000-0003-2366-3598$$aGutiérrez, L.$$uUniversidad de Zaragoza
000124000 700__ $$aBarber, D. F.
000124000 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000124000 773__ $$g20 (2022), 543 [23 pp.]$$pJ. nanobiotechnol.$$tJournal of Nanobiotechnology$$x1477-3155
000124000 8564_ $$s7727691$$uhttps://zaguan.unizar.es/record/124000/files/texto_completo.pdf$$yVersión publicada
000124000 8564_ $$s2214439$$uhttps://zaguan.unizar.es/record/124000/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124000 909CO $$ooai:zaguan.unizar.es:124000$$particulos$$pdriver
000124000 951__ $$a2024-03-18-16:58:31
000124000 980__ $$aARTICLE