000124002 001__ 124002
000124002 005__ 20230914083804.0
000124002 0247_ $$2doi$$a10.1515/almed-2022-0111
000124002 0248_ $$2sideral$$a132609
000124002 037__ $$aART-2022-132609
000124002 041__ $$aeng
000124002 100__ $$aSienes Bailo, P.
000124002 245__ $$aThe role of oxidative stress in neurodegenerative diseases and potential antioxidant therapies
000124002 260__ $$c2022
000124002 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124002 5203_ $$aObjectives: The central nervous system (CNS) is essential for homeostasis and controls the physiological functions of the body. However, the biochemical characteristics of the CNS make it especially vulnerable to oxidative damage (OS). This phenomenon compromises correct CNS functioning, leading to neurodegeneration and neuronal death. Contents: OS plays a crucial role in the physiopathology of neurodegenerative diseases. It is involved in multiple mechanisms of nucleic acid, protein, and lipid oxidation, thereby contributing to progressive brain damage. These mechanisms include mitochondrial dysfunction; excessive production of reactive oxygen and nitrogen species; deficiency of antioxidant defenses; protein oligomerization; cytokine production and inflammatory response; blood–brain barrier abnormalities; and proteasome dysfunction. All these dysfunctions are involved in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, or amyotrophic lateral sclerosis. Summary and outlook: A curative treatment is currently not available. Research is focused on the search for therapies that reduce oxidative damage and delay disease progression. In the recent years, researchers have focused their attention on the effects of antioxidant therapies.
000124002 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000124002 592__ $$a0.199$$b2022
000124002 593__ $$aMedical Laboratory Technology$$c2022$$dQ3
000124002 593__ $$aMedicine (miscellaneous)$$c2022$$dQ4
000124002 593__ $$aEducation$$c2022$$dQ4
000124002 594__ $$a0.7$$b2022
000124002 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124002 700__ $$aLlorente Martín, E.
000124002 700__ $$aCalmarza, P.
000124002 700__ $$aMontolio Breva, S.
000124002 700__ $$aBravo Gómez, A.
000124002 700__ $$aPozo Giráldez, A.
000124002 700__ $$aSánchez-Pascuala Callau, J. J.
000124002 700__ $$aVaquer Santamaría, J. M.
000124002 700__ $$aDayaldasani Khialani, A.
000124002 700__ $$aCerdá Micó, C.
000124002 700__ $$aCamps Andreu, J.
000124002 700__ $$aSáez Tormo, G.
000124002 700__ $$aFort Gallifa, I.
000124002 773__ $$g3, 4 (2022), 342-350$$pAdv. lab. med$$tAdvances in laboratory medicine$$x2628-491X
000124002 8564_ $$s453488$$uhttps://zaguan.unizar.es/record/124002/files/texto_completo.pdf$$yVersión publicada
000124002 8564_ $$s2945272$$uhttps://zaguan.unizar.es/record/124002/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124002 909CO $$ooai:zaguan.unizar.es:124002$$particulos$$pdriver
000124002 951__ $$a2023-09-13-15:23:14
000124002 980__ $$aARTICLE