000124005 001__ 124005 000124005 005__ 20240124152522.0 000124005 0247_ $$2doi$$a10.1016/j.psychres.2022.114975 000124005 0248_ $$2sideral$$a132626 000124005 037__ $$aART-2023-132626 000124005 041__ $$aeng 000124005 100__ $$aGarcia, A. 000124005 245__ $$aEfficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial 000124005 260__ $$c2023 000124005 5060_ $$aAccess copy available to the general public$$fUnrestricted 000124005 5203_ $$aBackground: The high prevalence of depression is partly attributable to the poor response of patients to first-line antidepressants. Multimodal programs that promote a healthy lifestyle are successful in treating depression when used as a complementary therapy, but their medium- and long-term benefits have not been demonstrated for patients with treatment-resistant depression (TRD). The main aim of this study was to compare the effectiveness of a lifestyle modification program (LMP) with mindfulness-based cognitive therapy (MBCT) and a placebo-control (written suggestions for lifestyle changes) in Spanish patients with TRD. Methods: This controlled clinical trial randomized 94 patients with TRD into 3 arms. The primary outcome was the Beck Depression Inventory-II (BDI-II) score at baseline, 2, 6 and 12 months. The secondary outcomes were changes in scores that evaluated quality-of-life, adherence to the Mediterranean diet, physical activity, and social support. Results: Relative to the placebo group, the LMP and MBCT groups had significantly better quality of life (p = 0.017; p = 0.027), and the LMP group had significantly better adherence to the Mediterranean diet (p<0.001) and reduced use of antidepressants (p = 0.036). However, the three groups showed no significant differences in BDI-II score. Limitations: Only about half of the planned 180 patients were recruited, in part due to the COVID-19 pandemic. Conclusions: There was no evidence that the LMP treatment significantly reduced symptoms of depression relative to the other groups during the COVID-19 lockdown. 000124005 536__ $$9info:eu-repo/grantAgreement/ES/MCINN/RTI2018-093590-B-I00$$9info:eu-repo/grantAgreement/ES/ISCIII/CP21-00080 000124005 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000124005 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000124005 700__ $$aYáñez, A. M. 000124005 700__ $$aBennasar-Veny, M. 000124005 700__ $$aNavarro, C. 000124005 700__ $$aSalva, J. 000124005 700__ $$aIbarra, O. 000124005 700__ $$aGómez-Juanes, R. 000124005 700__ $$aSerrano-Ripoll, M. J. 000124005 700__ $$0(orcid)0000-0001-6565-9699$$aOliván, B.$$uUniversidad de Zaragoza 000124005 700__ $$aGili, M. 000124005 700__ $$aRoca, M. 000124005 700__ $$aRiera-Serra, P. 000124005 700__ $$0(orcid)0000-0003-2683-7346$$aAguilar Latorre, A.$$uUniversidad de Zaragoza 000124005 700__ $$aMontero-Marin, J. 000124005 700__ $$aGarcía-Toro, M. 000124005 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social 000124005 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000124005 773__ $$g319 (2023), 114975 [9 pp.]$$pPsychiatry res.$$tPSYCHIATRY RESEARCH$$x0165-1781 000124005 8564_ $$s1338822$$uhttps://zaguan.unizar.es/record/124005/files/texto_completo.pdf$$yVersión publicada 000124005 8564_ $$s2215243$$uhttps://zaguan.unizar.es/record/124005/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000124005 909CO $$ooai:zaguan.unizar.es:124005$$particulos$$pdriver 000124005 951__ $$a2024-01-24-15:20:45 000124005 980__ $$aARTICLE