124005 20241125101129.0 doi 10.1016/j.psychres.2022.114975 sideral 132626 ART-2023-132626 eng Garcia, A. Efficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial 2023 Access copy available to the general public Unrestricted Background: The high prevalence of depression is partly attributable to the poor response of patients to first-line antidepressants. Multimodal programs that promote a healthy lifestyle are successful in treating depression when used as a complementary therapy, but their medium- and long-term benefits have not been demonstrated for patients with treatment-resistant depression (TRD). The main aim of this study was to compare the effectiveness of a lifestyle modification program (LMP) with mindfulness-based cognitive therapy (MBCT) and a placebo-control (written suggestions for lifestyle changes) in Spanish patients with TRD. Methods: This controlled clinical trial randomized 94 patients with TRD into 3 arms. The primary outcome was the Beck Depression Inventory-II (BDI-II) score at baseline, 2, 6 and 12 months. The secondary outcomes were changes in scores that evaluated quality-of-life, adherence to the Mediterranean diet, physical activity, and social support. Results: Relative to the placebo group, the LMP and MBCT groups had significantly better quality of life (p = 0.017; p = 0.027), and the LMP group had significantly better adherence to the Mediterranean diet (p<0.001) and reduced use of antidepressants (p = 0.036). However, the three groups showed no significant differences in BDI-II score. Limitations: Only about half of the planned 180 patients were recruited, in part due to the COVID-19 pandemic. Conclusions: There was no evidence that the LMP treatment significantly reduced symptoms of depression relative to the other groups during the COVID-19 lockdown. info:eu-repo/grantAgreement/ES/ISCIII/CP21-00080 info:eu-repo/grantAgreement/ES/MCINN/RTI2018-093590-B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.2 2023 PSYCHIATRY 50 / 279 = 0.179 2023 Q1 T1 PSYCHIATRY 50 / 279 = 0.179 2023 Q1 T1 2.189 2023 Psychiatry and Mental Health 2023 Q1 Biological Psychiatry 2023 Q1 17.4 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Yáñez, A. M. Bennasar-Veny, M. Navarro, C. Salva, J. Ibarra, O. Gómez-Juanes, R. Serrano-Ripoll, M. J. Oliván, B. Universidad de Zaragoza (orcid)0000-0001-6565-9699 Gili, M. Roca, M. Riera-Serra, P. Aguilar Latorre, A. Universidad de Zaragoza (orcid)0000-0003-2683-7346 Montero-Marin, J. García-Toro, M. 4009 740 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Social 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 319 (2023), 114975 [9 pp.] Psychiatry res. PSYCHIATRY RESEARCH 0165-1781 1338822 http://zaguan.unizar.es/record/124005/files/texto_completo.pdf Versión publicada 2215243 http://zaguan.unizar.es/record/124005/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:124005 articulos driver 2024-11-22-11:58:30 ARTICLE