000124037 001__ 124037
000124037 005__ 20240319081029.0
000124037 0247_ $$2doi$$a10.1021/acs.chemmater.2c01746
000124037 0248_ $$2sideral$$a132646
000124037 037__ $$aART-2022-132646
000124037 041__ $$aeng
000124037 100__ $$aAires, Antonio
000124037 245__ $$aEngineered protein-driven synthesis of tunable iron oxide nanoparticles as T1 and T2 magnetic resonance imaging contrast agents
000124037 260__ $$c2022
000124037 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124037 5203_ $$aIron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because of their biocompatibility and physicochemical properties. This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the tunable synthesis of ultrasmall IONPs. Rationally designed proteins, containing different number of metal-coordination sites, were evaluated to control the size and the physicochemical and magnetic properties of a set of protein-stabilized IONPs (Prot-IONPs). Prot-IONPs, synthesized through an optimized coprecipitation approach, presented good T1 and T2 relaxivity values, stability, and biocompatibility, showing potential for magnetic resonance imaging (MRI) applications.
000124037 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-111649RB-I00$$9info:eu-repo/grantAgreement/EC/H2020/101069356 /EU/Nano-Biological Contrast Agent Platform for MRI Imaging/Nano-imaging$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101069356 -Nano-imaging$$9info:eu-repo/grantAgreement/EC/H2020/648071/EU/Protein-based functional nanostructures/ProNANO$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 648071-ProNANO$$9info:eu-repo/grantAgreement/ES/MICINN/MDM-2017-0720$$9info:eu-repo/grantAgreement/ES/MICINN/PGC2018-096016-B-I00
000124037 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000124037 590__ $$a8.6$$b2022
000124037 592__ $$a2.869$$b2022
000124037 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b63 / 343 = 0.184$$c2022$$dQ1$$eT1
000124037 593__ $$aChemical Engineering (miscellaneous)$$c2022$$dQ1
000124037 591__ $$aCHEMISTRY, PHYSICAL$$b38 / 161 = 0.236$$c2022$$dQ1$$eT1
000124037 593__ $$aMaterials Chemistry$$c2022$$dQ1
000124037 593__ $$aChemistry (miscellaneous)$$c2022$$dQ1
000124037 594__ $$a15.9$$b2022
000124037 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124037 700__ $$0(orcid)0000-0002-0970-1917$$aFernández-Afonso, Yilian
000124037 700__ $$aGuedes, Gabriela
000124037 700__ $$aGuisasola, Eduardo
000124037 700__ $$0(orcid)0000-0003-2366-3598$$aGutiérrez, Lucía$$uUniversidad de Zaragoza
000124037 700__ $$aCortajarena, Aitziber L.
000124037 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000124037 773__ $$g34, 24 (2022), 10832-10841$$pChem. mater.$$tChemistry of materials$$x0897-4756
000124037 8564_ $$s7303722$$uhttps://zaguan.unizar.es/record/124037/files/texto_completo.pdf$$yVersión publicada
000124037 8564_ $$s3014700$$uhttps://zaguan.unizar.es/record/124037/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124037 909CO $$ooai:zaguan.unizar.es:124037$$particulos$$pdriver
000124037 951__ $$a2024-03-18-17:02:10
000124037 980__ $$aARTICLE