000124043 001__ 124043 000124043 005__ 20240731103319.0 000124043 0247_ $$2doi$$a10.3390/ijerph20010328 000124043 0248_ $$2sideral$$a132664 000124043 037__ $$aART-2023-132664 000124043 041__ $$aeng 000124043 100__ $$0(orcid)0000-0003-2448-1630$$aLozano del Hoyo, María Luisa,$$uUniversidad de Zaragoza 000124043 245__ $$aThe TELE-DD randomised controlled trial on treatment adherence in patients with type 2 diabetes and comorbid depression: clinical outcomes after 18-month follow-up 000124043 260__ $$c2023 000124043 5060_ $$aAccess copy available to the general public$$fUnrestricted 000124043 5203_ $$aClinical depression is associated with poorer adherence to hypoglycaemic medication in patients with diabetes mellitus, leading to poorer glycaemic control, diabetes management, and increased complications. The main aim of the TELE-DD trial was to demonstrate the efficacy of a proactive and psychoeducational telephonic intervention based on motivational interviewing and collaborative care to reduce nonadherence and improve prognosis in individuals with diabetes mellitus and concurrent depression. Design: The TELE-DD project is a three-phased prospective study including a nested randomised controlled trial. Methods: The baseline cohort included the entire population of adult patients diagnosed with type 2 diabetes and concurrent depression. A randomised controlled trial was conducted in a selection of patients from the baseline cohort, distributed into a control group (n = 192) and an intervention group (n = 192). Monthly telephonic interventions delivered by specifically trained research nurses were centred on a psychoeducational individualised monitoring protocol including motivational interviewing and collaborative care strategies. Clinical and patient-centred data were systematically collected during an 18-month follow-up including HbA1c, Patient Health Questionnaire, and the Diabetes Distress Scale. Results: During the trial, 18-month follow-up HbA1C levels significantly (p < 0.001) decreased in the intervention group at every follow-up from an average of 8.72 (SD:1.49) to 7.03 (SD:1.09), but slightly increased in the control group from 8.65 (SD:1.40) to 8.84 (SD:1.38). Similar positive results were obtained in depression severity and diabetes distress, LDL-cholesterol, and systolic and diastolic blood pressure, but only at the 18-month follow-up in body mass index reduction. Conclusions: This is the first trial to concurrently decrease biological and psychological outcomes with a monthly brief telephonic intervention, pointing out that a combined biopsychosocial intervention and collaborative care strategy is essential for current world health challenges. ClinicalTrials.gov Identifier: NCT04097483. Patient or Public Contribution: Diabetic patients not belonging to the TELE-DD population or trial sample were consulted during the study design to review and guarantee the clarity and understanding of the trial psychoeducational materials. 000124043 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B43-20R Grupo Agua y salud$$9info:eu-repo/grantAgreement/ES/ISCIII-MECD-IISZ/FI17-00180 000124043 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000124043 592__ $$a0.808$$b2023 000124043 593__ $$aHealth, Toxicology and Mutagenesis$$c2023$$dQ2 000124043 593__ $$aPublic Health, Environmental and Occupational Health$$c2023$$dQ2 000124043 593__ $$aPollution$$c2023$$dQ2 000124043 594__ $$a7.3$$b2023 000124043 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000124043 700__ $$0(orcid)0000-0002-6455-119X$$aFernández Rodrigo, María Teresa$$uUniversidad de Zaragoza 000124043 700__ $$0(orcid)0000-0001-7049-8295$$aUrcola Pardo, Fernando$$uUniversidad de Zaragoza 000124043 700__ $$0(orcid)0000-0003-2088-2007$$aMonreal Bartolomé, Alicia$$uUniversidad de Zaragoza 000124043 700__ $$aGracia Ruiz, Diana Cecilia 000124043 700__ $$aGómez Borao, Mercedes$$uUniversidad de Zaragoza 000124043 700__ $$aAlcázar Artigas, Ana Belén 000124043 700__ $$aMartínez Casbas, José Pedro$$uUniversidad de Zaragoza 000124043 700__ $$aAceituno Casas, Alexandra 000124043 700__ $$aAndaluz Funcia, María Teresa 000124043 700__ $$0(orcid)0000-0003-4013-1315$$aRoy Delgado, Juan Francisco$$uUniversidad de Zaragoza 000124043 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería 000124043 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000124043 773__ $$g20, 1 (2023), 328 [18 pp]$$pInt. j. environ. res. public health$$tInternational journal of environmental research and public health$$x1661-7827 000124043 8564_ $$s1461003$$uhttps://zaguan.unizar.es/record/124043/files/texto_completo.pdf$$yVersión publicada 000124043 8564_ $$s2845757$$uhttps://zaguan.unizar.es/record/124043/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000124043 909CO $$ooai:zaguan.unizar.es:124043$$particulos$$pdriver 000124043 951__ $$a2024-07-31-09:42:25 000124043 980__ $$aARTICLE