124047 20230914083808.0 doi 10.1021/jacsau.1c00477 sideral 132675 ART-2022-132675 eng Rodenes, Miriam Molecularly engineering Defective Basal Planes in Molybdenum Sulfide for the direct synthesis of Benzimidazoles by Reductive Coupling of Dinitroarenes with Aldehydes 2022 Access copy available to the general public Unrestricted Developing more sustainable catalytic processes for preparing N-heterocyclic compounds in a less costly, compact, and greener manner from cheap and readily available reagents is highly desirable in modern synthetic chemistry. Herein, we report a straightforward synthesis of benzimidazoles by reductive coupling of o-dinitroarenes with aldehydes in the presence of molecular hydrogen. An innovative molecular cluster-based synthetic strategy that employs Mo3S4 complexes as precursors have been used to engineer a sulfur-deficient molybdenum disulfide (MoS2)-type material displaying structural defects on both the naturally occurring edge positions and along the typically inactive basal planes. By applying this catalyst, a broad range of functionalized 2-substituted benzimidazoles, including bioactive compounds, can be selectively synthesized by such a direct hydrogenative coupling protocol even in the presence of hydrogenation-sensitive functional groups, such as double and triple carbon–carbon bonds, nitrile and ester groups, and halogens as well as diverse types of heteroarenes. info:eu-repo/grantAgreement/ES/DGA-FEDER/E31-17R info:eu-repo/grantAgreement/ES/MICINN-AEI-FEDER/PID2019-105881RB-I00 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 5.3 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gonell, Francisco Martín, Santiago Universidad de Zaragoza (orcid)0000-0001-9193-3874 Corma, Avelino Sorribes, Iván 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 2, 3 (2022), 601-612 JACS Au 2691-3704 4164729 http://zaguan.unizar.es/record/124047/files/texto_completo.pdf Versión publicada 3239624 http://zaguan.unizar.es/record/124047/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:124047 articulos driver 2023-09-13-15:27:29 ARTICLE