000124077 001__ 124077
000124077 005__ 20240319081030.0
000124077 0247_ $$2doi$$a10.1021/acsapm.2c01553
000124077 0248_ $$2sideral$$a132651
000124077 037__ $$aART-2022-132651
000124077 041__ $$aeng
000124077 100__ $$0(orcid)0000-0003-0063-9456$$aSan Anselmo, María
000124077 245__ $$aHeparin-coated dendronized hyperbranched polymers for antimalarial targeted delivery
000124077 260__ $$c2022
000124077 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124077 5203_ $$aThe rampant evolution of resistance in Plasmodium to all existing antimalarial drugs calls for the development of improved therapeutic compounds and of adequate targeted delivery strategies for them. Loading antimalarials in nanocarriers specifically targeted to the parasite will contribute to the administration of lower overall doses, with reduced side effects for the patient, and of higher local amounts to parasitized cells for an increased lethality toward the pathogen. Here, we report the development of dendronized hyperbranched polymers (DHPs), with capacity for antimalarial loading, that are coated with heparin for their specific targeting to red blood cells parasitized by Plasmodium falciparum. The resulting DHP–heparin complexes exhibit the intrinsic antimalarial activity of heparin, with an IC50 of ca. 400 nM, added to its specific targeting to P. falciparum-infected (vs noninfected) erythrocytes. DHP–heparin nanocarriers represent a potentially interesting contribution to the limited family of structures described so far for the loading and targeted delivery of current and future antimalarial compounds.
000124077 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E47-20R$$9info:eu-repo/grantAgreement/ES/MCIU/BES-2016-078774$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/RTI2018-094579-B-I00$$9info:eu-repo/grantAgreement/ES/MICINN/CEX2018-000806-S$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00
000124077 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000124077 590__ $$a5.0$$b2022
000124077 592__ $$a0.999$$b2022
000124077 591__ $$aPOLYMER SCIENCE$$b16 / 85 = 0.188$$c2022$$dQ1$$eT1
000124077 593__ $$aOrganic Chemistry$$c2022$$dQ1
000124077 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b117 / 343 = 0.341$$c2022$$dQ2$$eT2
000124077 593__ $$aProcess Chemistry and Technology$$c2022$$dQ1
000124077 593__ $$aPolymers and Plastics$$c2022$$dQ1
000124077 594__ $$a6.7$$b2022
000124077 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124077 700__ $$aLantero, Elena
000124077 700__ $$aAvalos-Padilla, Yunuen
000124077 700__ $$aBouzón-Arnáiz, Inés
000124077 700__ $$aRamírez, Miriam
000124077 700__ $$aPostigo, Alejandro$$uUniversidad de Zaragoza
000124077 700__ $$0(orcid)0000-0001-9866-6633$$aSerrano, José Luis$$uUniversidad de Zaragoza
000124077 700__ $$0(orcid)0000-0001-7091-077X$$aSierra, Teresa
000124077 700__ $$0(orcid)0000-0003-3109-4284$$aHernández-Ainsa, Silvia$$uUniversidad de Zaragoza
000124077 700__ $$aFernàndez-Busquets, Xavier
000124077 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000124077 773__ $$g5, 1 (2022), 381-390$$pACS appl. polymer. mater.$$tACS applied polymer materials$$x2637-6105
000124077 8564_ $$s5791077$$uhttps://zaguan.unizar.es/record/124077/files/texto_completo.pdf$$yVersión publicada
000124077 8564_ $$s3059288$$uhttps://zaguan.unizar.es/record/124077/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124077 909CO $$ooai:zaguan.unizar.es:124077$$particulos$$pdriver
000124077 951__ $$a2024-03-18-17:05:36
000124077 980__ $$aARTICLE