000124355 001__ 124355
000124355 005__ 20241125101128.0
000124355 0247_ $$2doi$$a10.1016/j.jmbbm.2023.105661
000124355 0248_ $$2sideral$$a132689
000124355 037__ $$aART-2023-132689
000124355 041__ $$aeng
000124355 100__ $$aPérez-Benito, Ángela$$uUniversidad de Zaragoza
000124355 245__ $$aComputational modelling of the mechanical behaviour of protein-based hydrogels
000124355 260__ $$c2023
000124355 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124355 5203_ $$aProtein-based hydrogels have been extensively studied in the field of biomaterials given their ability to mimic living tissues and their special resemblance to the extracellular matrix. Despite this, the methods used for the control of mechanical properties of hydrogels are very limited, focusing mainly on their elasticity, with an often unrealistic characterization of mechanical properties such as extensibility, stiffness and viscoelasticity. Being able to control these properties is essential for the development of new biomaterials, since it has been demonstrated that mechanical properties affect cell behaviour and biological processes. To better understand the mechanical behaviour of these biopolymers, a computational model is here developed to characterize the mechanical behaviour of two different protein-based hydrogels. Strain–stress tests and stress-relaxation tests are evaluated computationally and compared to the results obtained experimentally in a previous work. To achieve this goal the Finite Element Method is used, combining hyperelastic and viscoelastic models. Different hyperelastic constitutive models (Mooney–Rivlin, Neo-Hookean, first and third order Ogden, and Yeoh) are proposed to estimate the mechanical properties of the protein-based hydrogels by least-square fitting of the in-vitro uniaxial test results. Among these models, the first order Ogden model with a viscoelastic model defined in Prony parameters better reproduces the strain–stress response and the change of stiffness with strain observed in the in-vitro tests.
000124355 536__ $$9info:eu-repo/grantAgreement/ES/DGA/2019-23$$9info:eu-repo/grantAgreement/EC/H2020/101018587/EU/Individual and Collective Migration of the Immune Cellular System/ICoMICS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101018587-ICoMICS$$9info:eu-repo/grantAgreement/ES/MINECO/BIO2017-83640-P$$9info:eu-repo/grantAgreement/ES/MICINN/PLEC2021-007709/AEI/10.13039/501100011033$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/PID2021-122409OB-C21$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2015-073191
000124355 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000124355 590__ $$a3.3$$b2023
000124355 592__ $$a0.748$$b2023
000124355 591__ $$aENGINEERING, BIOMEDICAL$$b53 / 123 = 0.431$$c2023$$dQ2$$eT2
000124355 593__ $$aMechanics of Materials$$c2023$$dQ1
000124355 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b32 / 53 = 0.604$$c2023$$dQ3$$eT2
000124355 593__ $$aBiomaterials$$c2023$$dQ2
000124355 593__ $$aBiomedical Engineering$$c2023$$dQ2
000124355 594__ $$a7.2$$b2023
000124355 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124355 700__ $$aHuerta-López, Carla
000124355 700__ $$aAlegre-Cebollada, Jorge
000124355 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, José Manuel$$uUniversidad de Zaragoza
000124355 700__ $$0(orcid)0000-0001-8324-5596$$aHervas-Raluy, Silvia$$uUniversidad de Zaragoza
000124355 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000124355 773__ $$g138 (2023), 105661 [10 pp.]$$pJ. mech. behav. boomed. mater.$$tJournal of the Mechanical Behavior of Biomedical Materials$$x1751-6161
000124355 8564_ $$s2035404$$uhttps://zaguan.unizar.es/record/124355/files/texto_completo.pdf$$yVersión publicada
000124355 8564_ $$s2773826$$uhttps://zaguan.unizar.es/record/124355/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124355 909CO $$ooai:zaguan.unizar.es:124355$$particulos$$pdriver
000124355 951__ $$a2024-11-22-11:58:17
000124355 980__ $$aARTICLE