Simulations of surface charge density changes during the untreated solid tumour growth

Bory Prevez, Henry ; Soutelo Jimenez, Argenis Adrian ; Roca Oria, Eduardo José ; Heredia Kindelán, José Alejandro ; Morales González, Maraelys ; Villar Goris, Narciso Antonio ; Hernández Mesa, Nibaldo ; Sierra González, Victoriano Gustavo ; Infantes Frometa, Yenia ; Montijano, Juan Ignacio (Universidad de Zaragoza) ; Bergues Cabrales, Luis Enrique

Resumen: Understanding untreated tumour growth kinetics and its intrinsic behaviour is interesting and intriguing. The aim of this study is to propose an approximate analytical expression that allows us to simulate changes in surface charge density at the cancer-surrounding healthy tissue interface during the untreated solid tumour growth. For this, the Gompertz and Poisson equations are used. Simulations reveal that the unperturbed solid tumour growth is closely related to changes in the surface charge density over time between the tumour and the surrounding healthy tissue. Furthermore, the unperturbed solid tumour growth is governed by temporal changes in this surface charge density. It is concluded that results corroborate the correspondence between the electrical and physiological parameters in the untreated cancer, which may have an essential role in its growth, progression, metastasis and protection against immune system attack and anti-cancer therapies. In addition, the knowledge of surface charge density changes at the cancer-surrounding healthy tissue interface may be relevant when redesigning the molecules in chemotherapy and immunotherapy taking into account their polarities. This can also be true in the design of completely novel therapies.

Idioma: Inglés

DOI: 10.1098/rsos.220552

Año: 2022

Publicado en: Royal Society Open Science 9, 11 (2022), 220552 [16 pp.]
ISSN: 2054-5703

Factor impacto JCR: 3.5 (2022)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 28 / 73 = 0.384 (2022) - Q2 - T2

Factor impacto CITESCORE: 6.0 - General (Q1)

Factor impacto SCIMAGO: 0.841 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-109045GB-C31

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Matemática Aplicada (Dpto. Matemática Aplicada)