124368 20241125101129.0 doi 10.3390/cancers15030871 sideral 132865 ART-2023-132865 eng Laredo, V. Risk of cancer in patients with inflammatory bowel diseases and keys for patient management 2023 Access copy available to the general public Unrestricted Chronic inflammation in patients with Inflammatory Bowel Disease (IBD) leads to an increased risk of colorectal cancer, small bowel cancer, intestinal lymphoma and cholangiocarcinoma. However, treatments for IBD have also been associated with an increased risk of neoplasms. Patients receiving Thiopurines (TPs) have an increased risk of hematologic malignancies, non-melanoma skin cancer, urinary tract neoplasms and cervical cancer. Anti-TNFs have been associated with a higher risk of neoplasms, mainly lymphomas and melanomas; however, the data are controversial, and some recent studies do not confirm the association. Nevertheless, other biologic agents, such as ustekinumab and vedolizumab, have not shown an increased risk of any neoplasm to date. The risk of malignancies with tofacitinib exists, but its magnitude and relationship with previous treatment with TPs is not defined, so more studies from daily clinical practice are needed. Although biologic therapy seems to be safe for patients with current cancer or a prior history of cancer, as has been demonstrated in other chronic inflammatory conditions, prospective studies in this specific population are needed. Until that time, it is crucial to manage such conditions via the combined clinical expertise of the gastroenterologist and oncologist. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.5 2023 ONCOLOGY 78 / 322 = 0.242 2023 Q1 T1 1.391 2023 Oncology 2023 Q1 Cancer Research 2023 Q2 8.0 2023 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion García Mateo, S. Universidad de Zaragoza Martínez Domínguez, S. J. Universidad de Zaragoza López de la Cruz, J. (orcid)0000-0002-2945-7368 Gargallo Puyuelo, C. J. Universidad de Zaragoza (orcid)0000-0002-3545-2707 Gomollón, F. Universidad de Zaragoza (orcid)0000-0003-0076-3529 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 15, 3 (2023), 871 [18 pp.] Cancers Cancers 2072-6694 692113 http://zaguan.unizar.es/record/124368/files/texto_completo.pdf Versión publicada 2649506 http://zaguan.unizar.es/record/124368/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:124368 articulos driver 2024-11-22-11:58:21 ARTICLE