000124385 001__ 124385
000124385 005__ 20240319081029.0
000124385 0247_ $$2doi$$a10.1038/s41537-021-00196-7
000124385 0248_ $$2sideral$$a132747
000124385 037__ $$aART-2022-132747
000124385 041__ $$aeng
000124385 100__ $$aPina-Camacho, Laura
000124385 245__ $$aCortical thinning over two years after first-episode psychosis depends on age of onset
000124385 260__ $$c2022
000124385 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124385 5203_ $$aFirst-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe.
000124385 536__ $$9info:eu-repo/grantAgreement/EC/FP7/603196/EU/Translating neuroimaging findings from research into clinical practice/PSYSCAN$$9info:eu-repo/grantAgreement/EC/H2020/115916/EU/Psychiatric Ratings using Intermediate Stratified Markers/PRISM$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115916-PRISM$$9info:eu-repo/grantAgreement/EC/H2020/777394/EU/Autism Innovative Medicine Studies – 2 – Trials/AIMS-2-TRIALS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 777394-AIMS-2-TRIALS$$9info:eu-repo/grantAgreement/ES/ISCIII/PI08-0208$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI17-01997$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI20-01342$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/CIBERSAM$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00612$$9info:eu-repo/grantAgreement/ES/MINECO/ISCIII-PI081203$$9info:eu-repo/grantAgreement/ES/MINECO/ISCIII-PI1101686$$9info:eu-repo/grantAgreement/ES/MINECO/PI14-00612
000124385 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000124385 590__ $$a0.0$$b2022
000124385 591__ $$aPSYCHIATRY
000124385 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124385 700__ $$aMartinez, Kenia
000124385 700__ $$aDiaz-Caneja, Covadonga M.
000124385 700__ $$aMezquida, Gisela
000124385 700__ $$aCuesta, Manuel J.
000124385 700__ $$aMoreno, Carmen
000124385 700__ $$aAmoretti, Silvia
000124385 700__ $$aGonzález-Pinto, Ana
000124385 700__ $$aArango, Celso
000124385 700__ $$aVieta, Eduard
000124385 700__ $$aCastro-Fornieles, Josefina
000124385 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000124385 700__ $$aFraguas, David
000124385 700__ $$aBernardo, Miguel
000124385 700__ $$aJanssen, Joost
000124385 700__ $$aParellada, Mara
000124385 700__ $$aMadero, Santiago
000124385 700__ $$aGómez-Ramiro, Marta
000124385 700__ $$aRodriguez-Toscano, Elisa
000124385 700__ $$aSantonja, Javier
000124385 700__ $$aZorrilla, Iñaki
000124385 700__ $$aGonzález-Ortega, Itxaso
000124385 700__ $$aFayed, Nicolás
000124385 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, Javier$$uUniversidad de Zaragoza
000124385 700__ $$aBerge, Daniel
000124385 700__ $$aToll, Alba
000124385 700__ $$aNacher, Juan
000124385 700__ $$aGarcía Martí, Gracián
000124385 700__ $$aSague-Vilavella, Maria
000124385 700__ $$aSanchez-Moreno, Jose
000124385 700__ $$ade la Serna, Elena
000124385 700__ $$aBaeza, Immaculada
000124385 700__ $$aSaiz-Masvidal, Cristina
000124385 700__ $$aContreras, Fernando
000124385 700__ $$aGonzález-Blanco, Leticia
000124385 700__ $$aBobes-Bascarán, Teresa
000124385 700__ $$aDompablo, Mónica
000124385 700__ $$aRodriguez-Jimenez, Roberto
000124385 700__ $$aUsall, Judith
000124385 700__ $$aButjosa, Anna
000124385 700__ $$aPomarol-Clotet, Edith
000124385 700__ $$aSarró, Salvador
000124385 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000124385 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000124385 773__ $$g8, 1 (2022), 1-9$$pSchizophrenia (Lond.)$$tSchizophrenia$$x2754-6993
000124385 8564_ $$s1559410$$uhttps://zaguan.unizar.es/record/124385/files/texto_completo.pdf$$yVersión publicada
000124385 8564_ $$s3146594$$uhttps://zaguan.unizar.es/record/124385/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124385 909CO $$ooai:zaguan.unizar.es:124385$$particulos$$pdriver
000124385 951__ $$a2024-03-18-17:04:10
000124385 980__ $$aARTICLE