000124432 001__ 124432
000124432 005__ 20241125101135.0
000124432 0247_ $$2doi$$a10.3389/fpsyg.2023.1076743
000124432 0248_ $$2sideral$$a132831
000124432 037__ $$aART-2023-132831
000124432 041__ $$aeng
000124432 100__ $$aLlana, T.
000124432 245__ $$aAssociation between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID
000124432 260__ $$c2023
000124432 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124432 5203_ $$aBackground and purposeThe coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. The persistent symptoms of anosmia or hyposmia were associated in previous studies with the development of memory impairment and mood disturbances. We aimed to investigate the association between the chronicity of reported olfactory dysfunction and subjective and objective cognitive performance in long-COVID patients and to explore whether their emotional symptoms are related to their cognition.MethodsOne hundred twenty-eight long-COVID participants were recruited. Reported symptomatology, subjective memory complaints, anxiety and depression symptomatology, and trait-anxiety were assessed. Subjective memory complaints and mood disturbances were compared among groups of participants with olfactory dysfunction as an acute (AOD), persistent (POD), or nonexistent (NOD) symptom. Seventy-six of the volunteers also participated in a face-to-face session to assess their objective performance on tests of general cognitive function and verbal declarative memory. Objective cognitive performance and mood disturbances were compared among the AOD, POD, and NOD groups.ResultsThe subjective memory complaints and the anxiety and depression symptoms were similar among the groups, but the score in general cognitive function was lower in the participants with symptoms of acute olfactory dysfunction than in those with no olfactory symptoms at any time. Participants’ memory complaints were positively related to their emotional symptoms. The relationship between depressive symptomatology and memory complaints interacted with the olfactory dysfunction, as it only occurred in the participants without symptoms of olfactory dysfunction. Depressive symptomatology and acute olfactory symptoms were negatively associated with general cognitive function and delayed memory performance. The months elapsed from diagnosis to assessment also predicted delayed memory performance. Anxious symptomatology was negatively associated with the immediate ability to recall verbal information in participants who did not present olfactory dysfunction in the acute phase of the infection.ConclusionOlfactory dysfunction in the acute phase of the infection by COVID-19 is related to cognitive deficits in objective tests, and mood disturbances are associated with self-reported and objective memory. These findings may contribute to further understanding the neuropsychological and emotional aspects of long-COVID.
000124432 536__ $$9info:eu-repo/grantAgreement/ES/DGA/S31-20D
000124432 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000124432 590__ $$a2.6$$b2023
000124432 592__ $$a0.8$$b2023
000124432 591__ $$aPSYCHOLOGY, MULTIDISCIPLINARY$$b56 / 219 = 0.256$$c2023$$dQ2$$eT1
000124432 593__ $$aPsychology (miscellaneous)$$c2023$$dQ2
000124432 594__ $$a5.3$$b2023
000124432 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124432 700__ $$aMéndez, M.
000124432 700__ $$0(orcid)0000-0001-6285-8158$$aGarcés-Arilla, S.$$uUniversidad de Zaragoza
000124432 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, V.$$uUniversidad de Zaragoza
000124432 700__ $$0(orcid)0000-0002-4249-602X$$aMéndez-López, M.$$uUniversidad de Zaragoza
000124432 700__ $$aJuan, M. C.
000124432 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000124432 773__ $$g14 (2023), 1076743 [19 pp.]$$pFront. psychol.$$tFrontiers in Psychology$$x1664-1078
000124432 8564_ $$s1234300$$uhttps://zaguan.unizar.es/record/124432/files/texto_completo.pdf$$yVersión publicada
000124432 8564_ $$s2508353$$uhttps://zaguan.unizar.es/record/124432/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124432 909CO $$ooai:zaguan.unizar.es:124432$$particulos$$pdriver
000124432 951__ $$a2024-11-22-12:00:39
000124432 980__ $$aARTICLE