124443 20241125101148.0 doi 10.1021/acscatal.2c05895 sideral 132904 ART-2023-132904 eng Tarifa, L. Iridium-Catalyzed Regio- and Diastereoselective Synthesis of C-Substituted Piperazines 2023 Access copy available to the general public Unrestricted Piperazine rings are essential motifs frequently found in commercial drugs. However, synthetic methodologies are mainly limited to N-substituted piperazines, preventing structural diversity. Disclosed herein is a straightforward catalytic method for the synthesis of complex C-substituted piperazines based on an uncommon head-to-head coupling of easily prepared imines. This 100% atom-economic process allows the selective formation of a sole diastereoisomer, a broad substrate scope, and a good functional group tolerance employing a bench-stable iridium catalyst under mild reaction conditions. Key to the success is the addition of N-oxides to the reaction mixture, as they notably enhance the catalytic activity and selectivity. info:eu-repo/grantAgreement/ES/AEI/PID2020-119512GB-I00 info:eu-repo/grantAgreement/ES/DGA/E50-20D info:eu-repo/grantAgreement/ES/MICINN/IJC-2018-035231-I info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 11.7 2023 CHEMISTRY, PHYSICAL 21 / 178 = 0.118 2023 Q1 T1 3.847 2023 Chemistry (miscellaneous) 2023 Q1 Catalysis 2023 Q1 20.8 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Río, M. P. del Asensio, L. López, J. A. Universidad de Zaragoza (orcid)0000-0003-4500-1974 Ciriano, M. A. (orcid)0000-0002-7188-8014 Geer, A. M. Universidad de Zaragoza (orcid)0000-0003-1115-6759 Tejel, C. (orcid)0000-0003-3306-0635 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 13, 5 (2023), 3148-3152 ACS catal. ACS CATALYSIS 2155-5435 2094089 http://zaguan.unizar.es/record/124443/files/texto_completo.pdf Versión publicada 2650499 http://zaguan.unizar.es/record/124443/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:124443 articulos driver 2024-11-22-12:05:18 ARTICLE