000124468 001__ 124468
000124468 005__ 20240705134219.0
000124468 0247_ $$2doi$$a10.1038/s41388-023-02604-x
000124468 0248_ $$2sideral$$a132909
000124468 037__ $$aART-2023-132909
000124468 041__ $$aeng
000124468 100__ $$aScott, E.
000124468 245__ $$aUpregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth
000124468 260__ $$c2023
000124468 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124468 5203_ $$aProstate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develop new treatments for advanced disease. Aberrant glycosylation is a hallmark of cancer implicated in tumour growth, metastasis, and immune evasion. One of the key drivers of aberrant glycosylation is the dysregulated expression of glycosylation enzymes within the cancer cell. Here, we demonstrate using multiple independent clinical cohorts that the glycosyltransferase enzyme GALNT7 is upregulated in prostate cancer tissue. We show GALNT7 can identify men with prostate cancer, using urine and blood samples, with improved diagnostic accuracy than serum PSA alone. We also show that GALNT7 levels remain high in progression to castrate-resistant disease, and using in vitro and in vivo models, reveal that GALNT7 promotes prostate tumour growth. Mechanistically, GALNT7 can modify O-glycosylation in prostate cancer cells and correlates with cell cycle and immune signalling pathways. Our study provides a new biomarker to aid the diagnosis of clinically significant disease and cements GALNT7-mediated O-glycosylation as an important driver of prostate cancer progression.
000124468 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000124468 592__ $$a2.334$$b2023
000124468 593__ $$aCancer Research$$c2023$$dQ1
000124468 593__ $$aMolecular Biology$$c2023$$dQ1
000124468 593__ $$aGenetics$$c2023$$dQ1
000124468 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000124468 700__ $$aHodgson, K.
000124468 700__ $$aCalle, B.
000124468 700__ $$aTurner, H.
000124468 700__ $$aCheung, K.
000124468 700__ $$aBermúdez, A.
000124468 700__ $$aGarcía Marqués, F. J.
000124468 700__ $$aPye, H.
000124468 700__ $$aYo, E. C.
000124468 700__ $$aIslam, K.
000124468 700__ $$aOo, H. Z.
000124468 700__ $$aMcClurg, U. L.
000124468 700__ $$aWilson, L.
000124468 700__ $$aThomas, H.
000124468 700__ $$aFrame, F. M.
000124468 700__ $$aOrozco-Moreno, M.
000124468 700__ $$aBastian, K.
000124468 700__ $$aArredondo, H. M.
000124468 700__ $$aRoustan, C.
000124468 700__ $$aGray, M. A.
000124468 700__ $$aKelly, L.
000124468 700__ $$aTolson, A.
000124468 700__ $$aMellor, E.
000124468 700__ $$aHysenaj, G.
000124468 700__ $$aGoode, E. A.
000124468 700__ $$aGarnham, R.
000124468 700__ $$aDuxfield, A.
000124468 700__ $$aHeavey, S.
000124468 700__ $$aStopka-Farooqui, U.
000124468 700__ $$aHaider, A.
000124468 700__ $$aFreeman, A.
000124468 700__ $$aSingh, S.
000124468 700__ $$aJohnston, E. W.
000124468 700__ $$aPunwani, S.
000124468 700__ $$aKnight, B.
000124468 700__ $$aMcCullagh, P.
000124468 700__ $$aMcGrath, J.
000124468 700__ $$aCrundwell, M.
000124468 700__ $$aHarries, L.
000124468 700__ $$aBogdan, D.
000124468 700__ $$aWestaby, D.
000124468 700__ $$aFowler, G.
000124468 700__ $$aFlohr, P.
000124468 700__ $$aYuan, W.
000124468 700__ $$aSharp, A.
000124468 700__ $$aBono, J. de
000124468 700__ $$aMaitland, N. J.
000124468 700__ $$aWisnovsky, S.
000124468 700__ $$aBertozzi, C. R.
000124468 700__ $$aHeer, R.
000124468 700__ $$0(orcid)0000-0002-3122-9401$$aHurtado Guerrero, R.
000124468 700__ $$aDaugaard, M.
000124468 700__ $$aLeivo, J.
000124468 700__ $$aWhitaker, H
000124468 700__ $$aPitteri, S.
000124468 700__ $$aWang, N.
000124468 700__ $$aElliott, D. J.
000124468 700__ $$aSchumann, B.
000124468 700__ $$aMunkley, J.
000124468 773__ $$g42 (2023), 926–937$$pOncogene$$tONCOGENE$$x0950-9232
000124468 8564_ $$s9819044$$uhttps://zaguan.unizar.es/record/124468/files/texto_completo.pdf$$yVersión publicada
000124468 8564_ $$s3011989$$uhttps://zaguan.unizar.es/record/124468/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124468 909CO $$ooai:zaguan.unizar.es:124468$$particulos$$pdriver
000124468 951__ $$a2024-07-05-12:53:34
000124468 980__ $$aARTICLE