000124515 001__ 124515
000124515 005__ 20230322092604.0
000124515 037__ $$aTAZ-TFM-2023-104
000124515 041__ $$aeng
000124515 1001_ $$aSierra Aguilera, María Alejandra
000124515 24200 $$aIdentification of disease-related targets for red wine polyphenols
000124515 24500 $$aIdentificación de dianas relacionadas con enfermedades y polifenoles del vino tinto
000124515 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2023
000124515 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/
000124515 520__ $$aThe objetive of the study was to develop a database of polyphenols in red wine and identify posible targets. Using network pharmacology as a suitable tool to discover bioactive compounds for therapeutic targets with the combination of open source databases like PubChem, CTD, STITCH, STRING, DAVID, and more, it was possible to build a red wine polyphenol database with 144 polyphenols, identifying curated and inferred associations with diseases, genes, pathways, gene ontologies and protein-protein interactions.<br />Using the database it was possible to identify targets for lung cancer based on the genes that are critical according to the enrichment pathway, together with centrality and degree analysis, founding 23 polyphenols in red wine affecting TP53 related to Non-small cell Lung Cancer (NSCLC). <br /><br />
000124515 521__ $$aMáster Universitario en Biofísica y Biotecnología Cuantitativa / Master in Biophysics and Quantitative Biotechnology
000124515 540__ $$aDerechos regulados por licencia Creative Commons
000124515 700__ $$aFernández-Recio, Juan$$edir.
000124515 700__ $$aMedina Trullenque, María Milagros$$edir.
000124515 7102_ $$aUniversidad de Zaragoza$$b $$c
000124515 8560_ $$f859424@unizar.es
000124515 8564_ $$s10382173$$uhttps://zaguan.unizar.es/record/124515/files/TAZ-TFM-2023-104.pdf$$yMemoria (eng)
000124515 909CO $$ooai:zaguan.unizar.es:124515$$pdriver$$ptrabajos-fin-master
000124515 950__ $$a
000124515 951__ $$adeposita:2023-03-21
000124515 980__ $$aTAZ$$bTFM$$cCIEN
000124515 999__ $$a20230202210445.CREATION_DATE