000125261 001__ 125261
000125261 005__ 20240705134149.0
000125261 0247_ $$2doi$$a10.3389/fnut.2023.1079407
000125261 0248_ $$2sideral$$a132916
000125261 037__ $$aART-2023-132916
000125261 041__ $$aeng
000125261 100__ $$aLázaro, Iolanda
000125261 245__ $$aWalnut inclusion in a palm oil-based atherogenic diet promotes traits predicting stable atheroma plaque in Apoe-deficient mice
000125261 260__ $$c2023
000125261 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125261 5203_ $$aIntroduction: The lower rates of cardiovascular disease in Southern Europe could be partially explained by the low prevalence of lipid-rich atheroma plaques. Consumption of certain foods affects the progression and severity of atherosclerosis. We investigated whether the isocaloric inclusion of walnuts within an atherogenic diet prevents phenotypes predicting unstable atheroma plaque in a mouse model of accelerated atherosclerosis.
Methods: Apolipoprotein E-deficient male mice (10-week-old) were randomized to receive a control diet (9.6% of energy as fat, n = 14), a palm oil-based high-fat diet (43% of energy as fat, n = 15), or an isocaloric diet in which part of palm oil was replaced by walnuts in a dose equivalent to 30 g/day in humans (n = 14). All diets contained 0.2% cholesterol.
Results: After 15 weeks of intervention, there were no differences in size and extension in aortic atherosclerosis among groups. Compared to control diet, palm oil-diet induced features predicting unstable atheroma plaque (higher lipid content, necrosis, and calcification), and more advanced lesions (Stary score). Walnut inclusion attenuated these features. Palm oil-based diet also boosted inflammatory aortic storm (increased expression of chemokines, cytokines, inflammasome components, and M1 macrophage phenotype markers) and promoted defective efferocytosis. Such response was not observed in the walnut group. The walnut group’s differential activation of nuclear factor kappa B (NF-κB; downregulated) and Nrf2 (upregulated) in the atherosclerotic lesion could explain these findings.
Conclusion: The isocaloric inclusion of walnuts in an unhealthy high-fat diet promotes traits predicting stable advanced atheroma plaque in mid-life mice. This contributes novel evidence for the benefits of walnuts, even in an unhealthy dietary environment.
000125261 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01014$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-127741OB-I00
000125261 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125261 592__ $$a0.828$$b2023
000125261 593__ $$aFood Science$$c2023$$dQ1
000125261 593__ $$aNutrition and Dietetics$$c2023$$dQ2
000125261 593__ $$aEndocrinology, Diabetes and Metabolism$$c2023$$dQ2
000125261 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125261 700__ $$aBobi, Joaquim
000125261 700__ $$aCofán, Montserrat
000125261 700__ $$aKapravelou, Garyfallia
000125261 700__ $$aAmor, Antonio J.
000125261 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, Joaquin$$uUniversidad de Zaragoza
000125261 700__ $$aGómez-Guerrero, Carmen
000125261 700__ $$aOrtega, Emilio
000125261 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesus$$uUniversidad de Zaragoza
000125261 700__ $$aDantas, Ana Paula
000125261 700__ $$aSala-Vila, Aleix
000125261 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000125261 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000125261 773__ $$g10 (2023)$$pFront. Nutr.$$tFrontiers in Nutrition$$x2296-861X
000125261 8564_ $$s11638640$$uhttps://zaguan.unizar.es/record/125261/files/texto_completo.pdf$$yVersión publicada
000125261 8564_ $$s2418721$$uhttps://zaguan.unizar.es/record/125261/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125261 909CO $$ooai:zaguan.unizar.es:125261$$particulos$$pdriver
000125261 951__ $$a2024-07-05-12:48:10
000125261 980__ $$aARTICLE