000125272 001__ 125272
000125272 005__ 20231215091007.0
000125272 0247_ $$2doi$$a10.1016/j.mtchem.2023.101404
000125272 0248_ $$2sideral$$a132963
000125272 037__ $$aART-2023-132963
000125272 041__ $$aeng
000125272 100__ $$0(orcid)0000-0002-1791-0188$$aBonet-Aleta, J.$$uUniversidad de Zaragoza
000125272 245__ $$aSynergistic assembly of gold and copper-iron oxide nanocatalysts to promote the simultaneous depletion of glucose and glutathione
000125272 260__ $$c2023
000125272 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125272 5203_ $$aGlucose and glutathione (GSH) are key biomolecules for the regulation and growth of tumor cells. The use of inorganic nanocatalysts in biomedicine to target and deplete such specific molecules represents a novel and promising strategy against cancer. In this work, we present a ternary assembled nanohybrid based on Au and CuFe2O4 with the capability to simultaneously deplete glucose and GSH and generate reactive oxidative species (ROS) in a cascade process. We describe an example of a synergistic heterogeneous nanoarchitecture able to maintain the glucose oxidase-like activity of Au while preventing its deactivation in the presence of GSH. Au sites remain active due to the rapid response of the Cu–Fe co-catalyst to deplete GSH levels. This example of hybrid heterostructure represents an appealing alternative with dual-activity within the tumor microenvironment (TME) for potential anticancer therapy.
000125272 536__ $$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE$$9info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN
000125272 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000125272 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125272 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, J.L.$$uUniversidad de Zaragoza
000125272 700__ $$0(orcid)0000-0002-6399-0852$$aSánchez-Uriel, L.
000125272 700__ $$aEncinas-Giménez, M.$$uUniversidad de Zaragoza
000125272 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000125272 700__ $$0(orcid)0000-0003-4160-9720$$aMartín-Duque, P.$$uUniversidad de Zaragoza
000125272 700__ $$0(orcid)0000-0001-7872-6301$$aMartínez, G.$$uUniversidad de Zaragoza
000125272 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, J.$$uUniversidad de Zaragoza
000125272 7102_ $$11013$$2275$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Estomatología
000125272 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000125272 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000125272 773__ $$g29 (2023), 101404 [8 pp.]$$tMaterials Today Chemistry$$x2468-5194
000125272 8564_ $$s2233039$$uhttps://zaguan.unizar.es/record/125272/files/texto_completo.pdf$$yVersión publicada
000125272 8564_ $$s2757052$$uhttps://zaguan.unizar.es/record/125272/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125272 909CO $$ooai:zaguan.unizar.es:125272$$particulos$$pdriver
000125272 951__ $$a2023-12-15-09:04:41
000125272 980__ $$aARTICLE