125272 20241125101148.0 doi 10.1016/j.mtchem.2023.101404 sideral 132963 ART-2023-132963 eng Bonet-Aleta, J. Universidad de Zaragoza (orcid)0000-0002-1791-0188 Synergistic assembly of gold and copper-iron oxide nanocatalysts to promote the simultaneous depletion of glucose and glutathione 2023 Access copy available to the general public Unrestricted Glucose and glutathione (GSH) are key biomolecules for the regulation and growth of tumor cells. The use of inorganic nanocatalysts in biomedicine to target and deplete such specific molecules represents a novel and promising strategy against cancer. In this work, we present a ternary assembled nanohybrid based on Au and CuFe2O4 with the capability to simultaneously deplete glucose and GSH and generate reactive oxidative species (ROS) in a cascade process. We describe an example of a synergistic heterogeneous nanoarchitecture able to maintain the glucose oxidase-like activity of Au while preventing its deactivation in the presence of GSH. Au sites remain active due to the rapid response of the Cu–Fe co-catalyst to deplete GSH levels. This example of hybrid heterostructure represents an appealing alternative with dual-activity within the tumor microenvironment (TME) for potential anticancer therapy. info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 6.7 2023 CHEMISTRY, MULTIDISCIPLINARY 49 / 231 = 0.212 2023 Q1 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 90 / 439 = 0.205 2023 Q1 T1 1.239 2023 Biomaterials 2023 Q1 Electronic, Optical and Magnetic Materials 2023 Q1 Polymers and Plastics 2023 Q1 Colloid and Surface Chemistry 2023 Q1 Materials Chemistry 2023 Q1 Catalysis 2023 Q1 8.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Hueso, J.L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 Sánchez-Uriel, L. (orcid)0000-0002-6399-0852 Encinas-Giménez, M. Universidad de Zaragoza Irusta, S. Universidad de Zaragoza (orcid)0000-0002-2966-9088 Martín-Duque, P. Universidad de Zaragoza (orcid)0000-0003-4160-9720 Martínez, G. Universidad de Zaragoza (orcid)0000-0001-7872-6301 Santamaría, J. Universidad de Zaragoza (orcid)0000-0002-8701-9745 1013 275 Universidad de Zaragoza Dpto. Cirugía Área Estomatología 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 29 (2023), 101404 [8 pp.] Materials Today Chemistry 2468-5194 2233039 http://zaguan.unizar.es/record/125272/files/texto_completo.pdf Versión publicada 2757052 http://zaguan.unizar.es/record/125272/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:125272 articulos driver 2024-11-22-12:05:22 ARTICLE