125279 20240731103358.0 doi 10.3390/ijerph20065161 sideral 132951 ART-2023-132951 eng Lavalle, Raffaele The impact of COVID-19 lockdown on adults with major depressive disorder from Catalonia: a decentralized longitudinal study 2023 Access copy available to the general public Unrestricted The present study analyzes the effects of each containment phase of the first COVID-19 wave on depression levels in a cohort of 121 adults with a history of major depressive disorder (MDD) from Catalonia recruited from 1 November 2019, to 16 October 2020. This analysis is part of the Remote Assessment of Disease and Relapse-MDD (RADAR-MDD) study. Depression was evaluated with the Patient Health Questionnaire-8 (PHQ-8), and anxiety was evaluated with the Generalized Anxiety Disorder-7 (GAD-7). Depression’s levels were explored across the phases (pre-lockdown, lockdown, and four post-lockdown phases) according to the restrictions of Spanish/Catalan governments. Then, a mixed model was fitted to estimate how depression varied over the phases. A significant rise in depression severity was found during the lockdown and phase 0 (early post-lockdown), compared with the pre-lockdown. Those with low pre-lockdown depression experienced an increase in depression severity during the “new normality”, while those with high pre-lockdown depression decreased compared with the pre-lockdown. These findings suggest that COVID-19 restrictions affected the depression level depending on their pre-lockdown depression severity. Individuals with low levels of depression are more reactive to external stimuli than those with more severe depression, so the lockdown may have worse detrimental effects on them. info:eu-repo/grantAgreement/EC/H2020/115902/EU/Remote Assessment of Disease and Relapse in Central Nervous System Disorders/RADAR-CNS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115902-RADAR-CNS info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 0.808 2023 Health, Toxicology and Mutagenesis 2023 Q2 Public Health, Environmental and Occupational Health 2023 Q2 Pollution 2023 Q2 7.3 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Condominas, Elena Haro, Josep Maria Giné-Vázquez, Iago Bailon, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Laporta, Estela Garcia, Ester Kontaxis, Spyridon Universidad de Zaragoza (orcid)0000-0002-1297-0691 Riquelme Alacid, Gemma Lombardini, Federica Preti, Antonio Peñarrubia-Maria, Maria Teresa Coromina, Marta Arranz, Belén Vilella, Elisabet Rubio-Alacid, Elena Matcham, Faith Lamers, Femke Hotopf, Matthew Penninx, Brenda W. J. H. Annas, Peter Narayan, Vaibhav Simblett, Sara K. Siddi, Sara RADAR-CNS Consortium 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 20, 6 (2023), 5161 [15 pp.] Int. j. environ. res. public health International journal of environmental research and public health 1661-7827 1365966 http://zaguan.unizar.es/record/125279/files/texto_completo.pdf Versión publicada 2887357 http://zaguan.unizar.es/record/125279/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:125279 articulos driver 2024-07-31-09:57:46 ARTICLE