000125292 001__ 125292
000125292 005__ 20241125101151.0
000125292 0247_ $$2doi$$a10.1039/d2nr06631a
000125292 0248_ $$2sideral$$a133031
000125292 037__ $$aART-2023-133031
000125292 041__ $$aeng
000125292 100__ $$aDotor, Laura$$uUniversidad de Zaragoza
000125292 245__ $$aLangmuir and Langmuir–Blodgett technologies as nanoarchitectonic tools for the incorporation of curcumin in membrane systems
000125292 260__ $$c2023
000125292 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125292 5203_ $$aCurcumin (CCM) is a molecule of particular interest in health applications due to its wide spectrum of benefits for humans. However, its water-insoluble character and low bioavailability have so far prevented its extended use as a therapeutic agent. Incorporation of CCM in drug delivery vehicles (liposomes, vesicles, exosomes, etc.) is expected to contribute to increasing its bioavailability. Studies of the affinity of CCM with the components of the membrane systems of such vehicles and determination of factors that may enhance curcumin entrapment in biological membranes are of fundamental importance. To that end, here we take advantage of the nanoarchitectonic capabilities of the Langmuir technique for the construction of model cell membranes and determination of thermodynamic properties in mixed films. The obtained results may serve to: (i) provide some light on the miscibility of CCM with the components in the cell membrane and (ii) determine the optimal conditions for the fabrication of membrane systems incorporating CCM. For that, binary and ternary mixed Langmuir films of CCM, DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) and CHOL (cholesterol) have been prepared. Whilst binary mixtures of DPPC and CCM exhibit poor miscibility and even phase segregation, CHOL has shown itself as a key element to promote the incorporation of CCM in the phospholipidic membrane containing DPPC. Both the thermodynamic studies of the ternary Langmuir films and the Atomic Force Microscopy (AFM) images of Langmuir–Blodgett films have shown that ternary mixed films with a molar fraction composition of xDPPC/xCHOL/xCCM = 0.4/0.4/0.2 exhibit good miscibility, stability, and result in monolayers with a very homogeneous topography.
000125292 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E31-20R
000125292 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125292 590__ $$a5.8$$b2023
000125292 592__ $$a1.416$$b2023
000125292 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b109 / 439 = 0.248$$c2023$$dQ1$$eT1
000125292 593__ $$aNanoscience and Nanotechnology$$c2023$$dQ1
000125292 591__ $$aPHYSICS, APPLIED$$b33 / 179 = 0.184$$c2023$$dQ1$$eT1
000125292 593__ $$aMaterials Science (miscellaneous)$$c2023$$dQ1
000125292 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b58 / 231 = 0.251$$c2023$$dQ2$$eT1
000125292 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b42 / 141 = 0.298$$c2023$$dQ2$$eT1
000125292 594__ $$a12.1$$b2023
000125292 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125292 700__ $$aGarcía-Pinilla, José Miguel
000125292 700__ $$0(orcid)0000-0001-9193-3874$$aMartín, Santiago$$uUniversidad de Zaragoza
000125292 700__ $$0(orcid)0000-0002-4729-9578$$aCea, Pilar$$uUniversidad de Zaragoza
000125292 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000125292 773__ $$g15, 6 (2023), 2891-2903$$pNanoscale$$tNanoscale$$x2040-3364
000125292 8564_ $$s2357733$$uhttps://zaguan.unizar.es/record/125292/files/texto_completo.pdf$$yVersión publicada
000125292 8564_ $$s2644996$$uhttps://zaguan.unizar.es/record/125292/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125292 909CO $$ooai:zaguan.unizar.es:125292$$particulos$$pdriver
000125292 951__ $$a2024-11-22-12:06:45
000125292 980__ $$aARTICLE