125292 20241125101151.0 doi 10.1039/d2nr06631a sideral 133031 ART-2023-133031 eng Dotor, Laura Universidad de Zaragoza Langmuir and Langmuir–Blodgett technologies as nanoarchitectonic tools for the incorporation of curcumin in membrane systems 2023 Access copy available to the general public Unrestricted Curcumin (CCM) is a molecule of particular interest in health applications due to its wide spectrum of benefits for humans. However, its water-insoluble character and low bioavailability have so far prevented its extended use as a therapeutic agent. Incorporation of CCM in drug delivery vehicles (liposomes, vesicles, exosomes, etc.) is expected to contribute to increasing its bioavailability. Studies of the affinity of CCM with the components of the membrane systems of such vehicles and determination of factors that may enhance curcumin entrapment in biological membranes are of fundamental importance. To that end, here we take advantage of the nanoarchitectonic capabilities of the Langmuir technique for the construction of model cell membranes and determination of thermodynamic properties in mixed films. The obtained results may serve to: (i) provide some light on the miscibility of CCM with the components in the cell membrane and (ii) determine the optimal conditions for the fabrication of membrane systems incorporating CCM. For that, binary and ternary mixed Langmuir films of CCM, DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) and CHOL (cholesterol) have been prepared. Whilst binary mixtures of DPPC and CCM exhibit poor miscibility and even phase segregation, CHOL has shown itself as a key element to promote the incorporation of CCM in the phospholipidic membrane containing DPPC. Both the thermodynamic studies of the ternary Langmuir films and the Atomic Force Microscopy (AFM) images of Langmuir–Blodgett films have shown that ternary mixed films with a molar fraction composition of xDPPC/xCHOL/xCCM = 0.4/0.4/0.2 exhibit good miscibility, stability, and result in monolayers with a very homogeneous topography. info:eu-repo/grantAgreement/ES/DGA-FSE/E31-20R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.8 2023 MATERIALS SCIENCE, MULTIDISCIPLINARY 109 / 439 = 0.248 2023 Q1 T1 PHYSICS, APPLIED 33 / 179 = 0.184 2023 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 58 / 231 = 0.251 2023 Q2 T1 NANOSCIENCE & NANOTECHNOLOGY 42 / 141 = 0.298 2023 Q2 T1 1.416 2023 Nanoscience and Nanotechnology 2023 Q1 Materials Science (miscellaneous) 2023 Q1 12.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion García-Pinilla, José Miguel Martín, Santiago Universidad de Zaragoza (orcid)0000-0001-9193-3874 Cea, Pilar Universidad de Zaragoza (orcid)0000-0002-4729-9578 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 15, 6 (2023), 2891-2903 Nanoscale Nanoscale 2040-3364 2357733 http://zaguan.unizar.es/record/125292/files/texto_completo.pdf Versión publicada 2644996 http://zaguan.unizar.es/record/125292/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:125292 articulos driver 2024-11-22-12:06:45 ARTICLE