000125339 001__ 125339
000125339 005__ 20230519145457.0
000125339 0247_ $$2doi$$a10.1007/s00417-021-05277-y
000125339 0248_ $$2sideral$$a126127
000125339 037__ $$aART-2021-126127
000125339 041__ $$aeng
000125339 100__ $$aBoned-Murillo A.
000125339 245__ $$aStructural and functional findings in patients with moderate diabetic retinopathy
000125339 260__ $$c2021
000125339 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125339 5203_ $$aPurpose: To evaluate structural and functional ocular changes in patients with type 2 diabetes mellitus (DM2) and moderate diabetic retinopathy (DR) without apparent diabetic macular edema (DME) assessed by optical coherence tomography (OCT) and microperimetry. Methods: This was a single-center cross-sectional descriptive study for which 75 healthy controls and 48 DM2 patients with moderate DR were included after applying exclusion criteria (one eye per patient was included). All eyes underwent a complete ophthalmic examination (axial length, macular imaging with swept-source OCT, and MAIA microperimetry). Macular thicknesses, ganglion cell complex (GCC) thicknesses, and central retinal sensitivity were compared between groups, and the relationships between the OCT and microperimetry parameters were evaluated. Results: Macular thickness was similar in both groups (242.17 ± 35.0 in the DM2 group vs 260.64 ± 73.9 in the control group). There was a diminution in the parafoveal area thickness in the DM2 group in the GCC complex. Retinal sensitivity was reduced in all sectors in the DM2 group. The central global value was 24.01 ± 5.7 in the DM2 group and 27.31 ± 2.7 in the control group (p < 0.001). Macular integrity was 80.89 ± 26.4 vs 64.70 ± 28.3 (p < 0.001) and total mean threshold was 23.90 ± 4.9 vs 26.48 ± 2.6 (p < 0.001) in the DM2 and control group, respectively. Moderate correlations were detected between the central sector of MAIA microperimetry and retina total central thickness (- 0.347; p = 0.0035). Age, visual acuity, and hemoglobin A1c levels also correlated with retinal sensitivity. Conclusion: Macular GCC thickness and central retinal sensitivity were reduced in patients with moderate DR without DME, suggesting the presence of macular neurodegeneration.[Figure not available: see fulltext.] © 2021, The Author(s).
000125339 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008
000125339 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125339 590__ $$a3.535$$b2021
000125339 591__ $$aOPHTHALMOLOGY$$b24 / 62 = 0.387$$c2021$$dQ2$$eT2
000125339 592__ $$a1.305$$b2021
000125339 593__ $$aSensory Systems$$c2021$$dQ1
000125339 593__ $$aOphthalmology$$c2021$$dQ1
000125339 594__ $$a5.0$$b2021
000125339 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125339 700__ $$aDiaz-Barreda M.D.
000125339 700__ $$0(orcid)0000-0002-2914-2593$$aFerreras A.$$uUniversidad de Zaragoza
000125339 700__ $$aBartolomé-Sesé I.
000125339 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital E.$$uUniversidad de Zaragoza
000125339 700__ $$aMontes-Rodríguez P.
000125339 700__ $$0(orcid)0000-0001-9876-5850$$aAscaso J.$$uUniversidad de Zaragoza
000125339 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla I.$$uUniversidad de Zaragoza
000125339 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000125339 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000125339 773__ $$g259, 12 (2021), 3625-3635$$pGraefe arch. clin. exp. ophthalmol.$$tGraefe''s Archive for Clinical and Experimental Ophthalmology$$x0721-832X
000125339 8564_ $$s1695955$$uhttps://zaguan.unizar.es/record/125339/files/texto_completo.pdf$$yVersión publicada
000125339 8564_ $$s1967523$$uhttps://zaguan.unizar.es/record/125339/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125339 909CO $$ooai:zaguan.unizar.es:125339$$particulos$$pdriver
000125339 951__ $$a2023-05-18-14:51:50
000125339 980__ $$aARTICLE