000125362 001__ 125362
000125362 005__ 20241125101149.0
000125362 0247_ $$2doi$$a10.1371/journal.pone.0280901
000125362 0248_ $$2sideral$$a133111
000125362 037__ $$aART-2023-133111
000125362 041__ $$aeng
000125362 100__ $$0(orcid)0000-0002-8334-4786$$aPérez, Cristina$$uUniversidad de Zaragoza
000125362 245__ $$aThe role of ß-adrenergic stimulation in QT interval adaptation to heart rate during stress test
000125362 260__ $$c2023
000125362 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125362 5203_ $$aThe adaptation lag of the QT interval after heart rate (HR) has been proposed as an arrhythmic risk marker. Most studies have quantified the QT adaptation lag in response to abrupt, step-like changes in HR induced by atrial pacing, in response to tilt test or during ambulatory recordings. Recent studies have introduced novel methods to quantify the QT adaptation lag to gradual, ramp-like HR changes in stress tests by evaluating the differences between the measured QT series and an estimated, memoryless QT series obtained from the instantaneous HR. These studies have observed the QT adaptation lag to progressively reduce when approaching the stress peak, with the underlying mechanisms being still unclear. This study analyzes the contribution of β-adrenergic stimulation to QT interval rate adaptation in response to gradual, ramp-like HR changes. We first quantify the QT adaptation lag in Coronary Artery Disease (CAD) patients undergoing stress test. To uncover the involved mechanisms, we use biophysically detailed computational models coupling descriptions of human ventricular electrophysiology and β-adrenergic signaling, from which we simulate ventricular action potentials and ECG signals. We characterize the adaptation of the simulated QT interval in response to the HR time series measured from each of the analyzed CAD patients. We show that, when the simulated ventricular tissue is subjected to a time-varying β-adrenergic stimulation pattern, with higher stimulation levels close to the stress peak, the simulated QT interval presents adaptation lags during exercise that are more similar to those measured from the patients than when subjected to constant β-adrenergic stimulation. During stress test recovery, constant and time-varying β-adrenergic stimulation patterns render similar adaptation lags, which are generally shorter than during exercise, in agreement with results from the patients. In conclusion, our findings support the role of time-varying β-adrenergic stimulation in contributing to QT interval adaptation to gradually increasing HR changes as those seen during the exercise phase of a stress test.
000125362 536__ $$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE$$9info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE$$9info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
000125362 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125362 590__ $$a2.9$$b2023
000125362 592__ $$a0.839$$b2023
000125362 591__ $$aMULTIDISCIPLINARY SCIENCES$$b32 / 134 = 0.239$$c2023$$dQ1$$eT1
000125362 593__ $$aMultidisciplinary$$c2023$$dQ1
000125362 594__ $$a6.2$$b2023
000125362 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125362 700__ $$aCebollada, Rubén
000125362 700__ $$0(orcid)0000-0003-2946-3044$$aMountris, Konstantinos A.
000125362 700__ $$aMartínez, Juan Pablo
000125362 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000125362 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000125362 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000125362 773__ $$g18, 1 (2023), e0280901 [22 pp.]$$pPLoS One$$tPLoS ONE$$x1932-6203
000125362 8564_ $$s1557185$$uhttps://zaguan.unizar.es/record/125362/files/texto_completo.pdf$$yVersión publicada
000125362 8564_ $$s2348521$$uhttps://zaguan.unizar.es/record/125362/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125362 909CO $$ooai:zaguan.unizar.es:125362$$particulos$$pdriver
000125362 951__ $$a2024-11-22-12:06:01
000125362 980__ $$aARTICLE