000125763 001__ 125763
000125763 005__ 20241125101133.0
000125763 0247_ $$2doi$$a10.3389/fendo.2023.1087958
000125763 0248_ $$2sideral$$a133339
000125763 037__ $$aART-2023-133339
000125763 041__ $$aeng
000125763 100__ $$0(orcid)0000-0001-7431-0376$$aAlonso-Ventura, Vanesa
000125763 245__ $$aAn elevated parametric thyroid feedback quantile-based index is associated with atrial fibrillation
000125763 260__ $$c2023
000125763 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125763 5203_ $$aAtrial fibrillation is associated with hyperthyroidism. Within the euthyroid range, it is also associated with high thyroxine (fT4), but not with thyrotropin (TSH). We aim to describe differences in thyroid regulation, measured by the Parametric Thyroid Feedback Quantile-Based Index (PTFQI), between patients with atrial fibrillation and the general population. Materials and methods: Thyroid parameters (PTFQI, TSH, and fT4) of a sample of 84 euthyroid subjects with atrial fibrillation (cases) were compared to a reference sample of euthyroid healthcare patients (controls). We calculated age and sex adjusted ORs for atrial fibrillation across tertiles of these parameters. Also, within cases, we studied thyroid parameters association with clinical characteristics of the atrial fibrillation. Results: After adjusting for age and sex, fT4 and PTFQI were higher in subjects with atrial fibrillation when compared to the general sample (p<0.01 and p=0.01, respectively). Atrial fibrillation ORs of the third versus the first PTFQI tertile was 1.88(95%CI 1.07,3.42), and there was a gradient across tertiles (p trend=0.02). Among atrial fibrillation patients, we observed that higher PTFQI was associated with sleep apnea/hypopnea syndrome (OSAS) (p=0.03), higher fT4 was associated with the presence of an arrhythmogenic trigger (p=0.02) and with heart failure (p<0.01), and higher TSH was also associated with OSAS (p<0.01). Conclusions: Euthyroid subjects with atrial fibrillation have an elevation of the pituitary TSH-inhibition threshold, measured by PTFQI, with respect to the general population. Within atrial fibrillation patients, high PTFQI was associated with OSAS, and high fT4 with heart failure. These results hint of the existence of a relationship between thyroid regulation and atrial fibrillation.
000125763 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00020
000125763 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125763 590__ $$a3.9$$b2023
000125763 592__ $$a1.24$$b2023
000125763 591__ $$aENDOCRINOLOGY & METABOLISM$$b51 / 186 = 0.274$$c2023$$dQ2$$eT1
000125763 593__ $$aEndocrinology, Diabetes and Metabolism$$c2023$$dQ1
000125763 594__ $$a5.7$$b2023
000125763 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125763 700__ $$aCampos-Magallón, Patricia
000125763 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000125763 700__ $$aCalmarza, Pilar
000125763 700__ $$0(orcid)0000-0001-7774-8840$$aCalvo-Gracía, Fernando$$uUniversidad de Zaragoza
000125763 700__ $$0(orcid)0000-0001-9578-6525$$aLou-Bonafonte, José Manuel$$uUniversidad de Zaragoza
000125763 700__ $$ade Diego-García, Patricia
000125763 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, José Antonio$$uUniversidad de Zaragoza
000125763 700__ $$aMarco-Benedí, Victoria$$uUniversidad de Zaragoza
000125763 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000125763 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000125763 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000125763 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000125763 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000125763 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000125763 773__ $$g14 (2023), [7 pp.]$$pFront. endocrinol.$$tFrontiers in Endocrinology$$x1664-2392
000125763 8564_ $$s564956$$uhttps://zaguan.unizar.es/record/125763/files/texto_completo.pdf$$yVersión publicada
000125763 8564_ $$s2227287$$uhttps://zaguan.unizar.es/record/125763/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125763 909CO $$ooai:zaguan.unizar.es:125763$$particulos$$pdriver
000125763 951__ $$a2024-11-22-11:59:39
000125763 980__ $$aARTICLE