125763 20241125101133.0 doi 10.3389/fendo.2023.1087958 sideral 133339 ART-2023-133339 eng Alonso-Ventura, Vanesa (orcid)0000-0001-7431-0376 An elevated parametric thyroid feedback quantile-based index is associated with atrial fibrillation 2023 Access copy available to the general public Unrestricted Atrial fibrillation is associated with hyperthyroidism. Within the euthyroid range, it is also associated with high thyroxine (fT4), but not with thyrotropin (TSH). We aim to describe differences in thyroid regulation, measured by the Parametric Thyroid Feedback Quantile-Based Index (PTFQI), between patients with atrial fibrillation and the general population. Materials and methods: Thyroid parameters (PTFQI, TSH, and fT4) of a sample of 84 euthyroid subjects with atrial fibrillation (cases) were compared to a reference sample of euthyroid healthcare patients (controls). We calculated age and sex adjusted ORs for atrial fibrillation across tertiles of these parameters. Also, within cases, we studied thyroid parameters association with clinical characteristics of the atrial fibrillation. Results: After adjusting for age and sex, fT4 and PTFQI were higher in subjects with atrial fibrillation when compared to the general sample (p<0.01 and p=0.01, respectively). Atrial fibrillation ORs of the third versus the first PTFQI tertile was 1.88(95%CI 1.07,3.42), and there was a gradient across tertiles (p trend=0.02). Among atrial fibrillation patients, we observed that higher PTFQI was associated with sleep apnea/hypopnea syndrome (OSAS) (p=0.03), higher fT4 was associated with the presence of an arrhythmogenic trigger (p=0.02) and with heart failure (p<0.01), and higher TSH was also associated with OSAS (p<0.01). Conclusions: Euthyroid subjects with atrial fibrillation have an elevation of the pituitary TSH-inhibition threshold, measured by PTFQI, with respect to the general population. Within atrial fibrillation patients, high PTFQI was associated with OSAS, and high fT4 with heart failure. These results hint of the existence of a relationship between thyroid regulation and atrial fibrillation. info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00020 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.9 2023 ENDOCRINOLOGY & METABOLISM 51 / 186 = 0.274 2023 Q2 T1 1.24 2023 Endocrinology, Diabetes and Metabolism 2023 Q1 5.7 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Campos-Magallón, Patricia Moreno-Franco, Belén Universidad de Zaragoza (orcid)0000-0003-0604-5042 Calmarza, Pilar Calvo-Gracía, Fernando Universidad de Zaragoza (orcid)0000-0001-7774-8840 Lou-Bonafonte, José Manuel Universidad de Zaragoza (orcid)0000-0001-9578-6525 de Diego-García, Patricia Casasnovas, José Antonio Universidad de Zaragoza (orcid)0000-0002-9887-2629 Marco-Benedí, Victoria Universidad de Zaragoza Civeira, Fernando Universidad de Zaragoza (orcid)0000-0001-7043-0952 Laclaustra, Martín Universidad de Zaragoza (orcid)0000-0003-3963-0846 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 14 (2023), [7 pp.] Front. endocrinol. Frontiers in Endocrinology 1664-2392 564956 http://zaguan.unizar.es/record/125763/files/texto_completo.pdf Versión publicada 2227287 http://zaguan.unizar.es/record/125763/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:125763 articulos driver 2024-11-22-11:59:39 ARTICLE