000125799 001__ 125799
000125799 005__ 20241125101136.0
000125799 0247_ $$2doi$$a10.3390/vetsci10040245
000125799 0248_ $$2sideral$$a133366
000125799 037__ $$aART-2023-133366
000125799 041__ $$aeng
000125799 100__ $$0(orcid)0000-0001-5084-6555$$aGarcía-Belenguer, Sylvia$$uUniversidad de Zaragoza
000125799 245__ $$aEffect of a Ketogenic medium chain Triglyceride-enriched diet on the fecal microbiota in canine idiopathic epilepsy: a pilot study
000125799 260__ $$c2023
000125799 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125799 5203_ $$aKetogenic diets have been successfully used in people and dogs with idiopathic epilepsy. This study examined the effect of a ketogenic medium chain triglycerides (MCT)- enriched diet administered for one month on the fecal microbiota of epileptic (n = 11) (six with drug-sensitive epilepsy, DSE; five with drug-refractory epilepsy, DRE) and non-epileptic beagle dogs (n = 12). A significant reduction after diet in the relative abundance of bacteria from the Actinobacteria phylum was observed in all dogs. Epileptic dogs showed a higher relative abundance of Lactobacillus compared with non-epileptic dogs at baseline but these differences disappeared after diet. Epileptic dogs also showed a significantly higher abundance of Negativicutes and Selenomonadales after dietary intervention. Baseline microbiota patterns were similar in non-epileptic beagles and dogs with DSE but significantly different from dogs with DRE. In non-epileptic and DSE groups, the MCT diet decreased the relative abundance of Firmicutes and increased that of Bacteroidetes and Fusobacteria, but the opposite effect was observed in dogs with DRE. These results suggest that the MCT diet effect would depend on individual baseline microbiota patterns and that ketogenic diets could help reduce gut microbiota differences between dogs with DRE and DSE.
000125799 536__ $$9info:eu-repo/grantAgreement/ES/DGA/LMP134-21$$9info:eu-repo/grantAgreement/ES/UZ/UZ2019-BIO-03
000125799 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125799 590__ $$a2.0$$b2023
000125799 592__ $$a0.552$$b2023
000125799 591__ $$aVETERINARY SCIENCES$$b43 / 167 = 0.257$$c2023$$dQ2$$eT1
000125799 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ1
000125799 594__ $$a2.9$$b2023
000125799 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125799 700__ $$0(orcid)0000-0002-5306-9365$$aGrasa, Laura$$uUniversidad de Zaragoza
000125799 700__ $$0(orcid)0000-0002-1581-3085$$aPalacio, Jorge$$uUniversidad de Zaragoza
000125799 700__ $$aMoral, Jon$$uUniversidad de Zaragoza
000125799 700__ $$0(orcid)0000-0003-1728-900X$$aRosado, Belén$$uUniversidad de Zaragoza
000125799 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000125799 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000125799 773__ $$g10, 4 (2023), 245 [13 pp.]$$tVeterinary Sciences$$x2306-7381
000125799 8564_ $$s1747844$$uhttps://zaguan.unizar.es/record/125799/files/texto_completo.pdf$$yVersión publicada
000125799 8564_ $$s2733542$$uhttps://zaguan.unizar.es/record/125799/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125799 909CO $$ooai:zaguan.unizar.es:125799$$particulos$$pdriver
000125799 951__ $$a2024-11-22-12:01:05
000125799 980__ $$aARTICLE